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Macrophages and Lymphocytes pp 361–369Cite as

Suppression of Immunological Responsiveness in Aged Mice and Its Relationship with Coenzyme Q Deficiency

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 121B))

Abstract

In 1957, Crane and his group (13) extracted from beef heart mitochondria, a new compound-coenzyme Q- “capable of undergoing reversible oxidation and reduction.” Today, coenzyme Q (Fig. 1) is accepted as a substance universally present in bacteria, plants and animals and as an essential constituent of the electron transport processes of respiration and coupled oxidative phosphorylation in mitochondria. The site of action of coenzyme Q is between NADH and succinate dehydrogenase and the cytochrome complex (reviewed in (17). Thus, coenzyme Q is indispensable for the intracellular energy metabolism and its deficiency is linked to the development of many pathological processes in cardiac, gingival and distrophic tissues of humans and animals. The existing literature was reviewed recently, and the creation of a new nosologic group of diseases was proposed--diseases of bioenergetics (19).

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Author information

Authors and Affiliations

  1. New England Institute, Ridgefield, Connecticut, USA

    E. G. Bliznakov

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  1. E. G. Bliznakov
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Editors and Affiliations

  1. Medical College of Virginia, Richmond, Virginia, USA

    Mario R. Escobar

  2. University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1980 Plenum Press, New York

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Bliznakov, E.G. (1980). Suppression of Immunological Responsiveness in Aged Mice and Its Relationship with Coenzyme Q Deficiency. In: Escobar, M.R., Friedman, H. (eds) Macrophages and Lymphocytes. Advances in Experimental Medicine and Biology, vol 121B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3593-1_32

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  • DOI: https://doi.org/10.1007/978-1-4684-3593-1_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3595-5

  • Online ISBN: 978-1-4684-3593-1

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