Activation of Pleural Macrophages by Intrapleural Application of Corynebacterium Parvum
Certain bacteria including Corynebacterium parvum (CP) have recently received much attention as nonspecific stimulants of the lymphoreticuloendothelial system (RES). When injected into experimental animals CP provides a chronic inflammatory stimulus leading to the extensive proliferation of lymphohistiocytic elements and activation of macrophages (9). This results in a significant enlargement of the spleen, liver, lung and lymph nodes. Induced changes in morphology are accompanied with many alterations in the functional state of the RES. Treated animals exhibit an increased phagocytic activity as evidenced by increased clearance of particulate material from the blood. They are more resistant to microbial infections and a variety of malignant tumors.
KeywordsTumor Nodule Nucleate Cell Pleural Cavity Mammary Carcinoma Cell Corynebacterium Parvum
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