Activation of Pleural Macrophages by Intrapleural Application of Corynebacterium Parvum

  • I. Bašić
  • B. Rodé
  • A. Kaštelan
  • L. Milas
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


Certain bacteria including Corynebacterium parvum (CP) have recently received much attention as nonspecific stimulants of the lymphoreticuloendothelial system (RES). When injected into experimental animals CP provides a chronic inflammatory stimulus leading to the extensive proliferation of lymphohistiocytic elements and activation of macrophages (9). This results in a significant enlargement of the spleen, liver, lung and lymph nodes. Induced changes in morphology are accompanied with many alterations in the functional state of the RES. Treated animals exhibit an increased phagocytic activity as evidenced by increased clearance of particulate material from the blood. They are more resistant to microbial infections and a variety of malignant tumors.


Tumor Nodule Nucleate Cell Pleural Cavity Mammary Carcinoma Cell Corynebacterium Parvum 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • I. Bašić
    • 1
  • B. Rodé
    • 1
  • A. Kaštelan
    • 1
  • L. Milas
    • 1
  1. 1.Department of Animal Physiology, Faculty of Natural Sci. & Math.Central Institute for Tumors and Allied DiseasesZagrebYugoslavia

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