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Glucan Induced Modification of Experimental Staphylococcus Aureus Infection in Normal, Leukemic and Immunosuppressed Mice

  • D. L. Williams
  • N. R. di Luzio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

Previous studies in our laboratory have demonstrated that glucan, a βl→ polyglucose component of the cell wall of Saccharomyces cerevisiae, nonspecifically activates lymphoreticular tissue (2,7,25). The intravenous administration of glucan results in a hypertrophy of the major RE organs with an intense activation and proliferation of macrophages (30–32). Glucan administration has been demonstrated to promote tumor regression and enhance survival in rats with an allogeneic Shay chloroleukemia (8) as well as in four syngeneic murine tumor models (10). Preliminary clinical investigations have demonstrated that intralesional administration of glucan results in prompt tumor necrosis with a concomitant monocytic infiltrate (23,24). Furthermore, Israel and Edelstein (19) have also reported that intratumoral administration of glucan resulted in necrosis of the lesion with a concomitant resolution of a distant nodule. Topical application of glucan resulted in disappearance of ulcerated lesions (19,23).

Keywords

Acute Pyelonephritis Saline Control Group Leukemic Mouse Aureus Infection Lymphocytic Leukemic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • D. L. Williams
    • 1
  • N. R. di Luzio
    • 1
  1. 1.Department of PhysiologyTulane University School of MedicineNew OrleansUSA

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