Glucan Induced Inhibition of Tumor Growth and Enhancement of Survival in a Variety of Transplantable and Spontaneous Murine Tumor Models

  • N. R. di Luzio
  • R. B. Mcnamee
  • D. L. Williams
  • K. M. Gilbert
  • M. A. Spanjers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

In recent years, attempts have been made to alter the course of neoplasia by augmenting host defense mechanisms. A number of adjuvants including bacterial vaccines and chemical compounds have been demonstrated to produce a nonspecific stimulation of the reticuloendothelial (RE) system and augment humoral and cellular immune response. The most commonly employed agents are Bacillus Calmette-Guerin (BCG) and Corynebacterium parvum (16,22). The efficacy of such nonspecific immunotherapy, however, varies depending upon the time and mode of injection (4,29,31) as well as the type of malignancy (29,33). In view of the virulent and antigeneic nature of bacterial adjuvants such as BCG, it is not surprising that complications have been observed on occasion following the intratumoral or intradermal injections of these agents (22,32). Furthermore, there is the threat of disseminated infection following inoculation with viable organisms in patients with immunodeficiency states secondary to malignancy (22) or in immunosuppressed animals (25). Indeed, Sparks, et al. (35) reported that rats receiving isonicotinic acid hydrazine and BCG intralesionally had better survival and smaller tumor volumes than BCG alone, possibly by inhibiting diversion of host response to the viable BCG organism.

Keywords

Leukemia Adenocarcinoma Penicillin Bacillus Streptomycin 

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • N. R. di Luzio
    • 1
  • R. B. Mcnamee
    • 1
  • D. L. Williams
    • 1
  • K. M. Gilbert
    • 1
  • M. A. Spanjers
    • 1
  1. 1.Department of PhysiologyTulane University School of MedicineNew OrleansUSA

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