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Therapeutic Effect of Intravenously Administered Yeast Glucan, in Mice Locally Infected by Mycobacterium Leprae

  • J. Delville
  • P. J. Jacques
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

The management of leprosy is still primarily based on chemotherapy and antibiotic therapy, e.g., on directly acting substances which are simply more toxic for the parasite than for the host cells. Little efforts have been devoted thus far to the evaluation of drug candidates whose indirect antiparasitic power involves stimulation of the natural mechanism of host-defense. The dramatic problem caused by rapid spreading of resistance to sulphones prompted us to correct that situation, namely by means of immunostimulating polysaccharides whose antiparasitic efficacy had already been established against experimental tumors (19). Particulate β 1–3 glucan extracted from the cell walls of Saccharomyces cerevisiae was first chosen, because of its ability to act on several strategic parameters of humoral and cellular immunity (1,5,8) leading to enhancement of nonspecific resistance in a first stage (6) followed by specific immunostimulation as a second stage. Especially relevant to the case of leprosy, in which macrophages are the host-cells to the parasitic mycobacteria, is that this glucan appears as a most potent and versatile reticuloendothelial (RE) system-stimulator (5) through both activation of preexisting macrophages and overproduction of fresh mononuclear phagocytes.

Keywords

Leprosy Bacillus Nonspecific Resistance Liver Sinusoidal Cell Yeast Glucan Bactericidal Nature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Browder, W., McNamee, R., Cohan, L., Taylor, D. and Di Luzio, N. R., J. Reticuloendothelial Soc., 20 (1976) 55 a.Google Scholar
  2. 2.
    Delville, J. and Jacques, P. J., Acta Leprologica, 66 /67 (1977) 101.Google Scholar
  3. 3.
    Delville, J. and Jacques, P. J., Arch. Intern. Physiol. Biochim., 85 (1977) 965.CrossRefGoogle Scholar
  4. 4.
    Delville, J. and Jacques, P. J., Biochem. Soc. Tras., 6 (1978) 395.Google Scholar
  5. 5.
    Di Luzio, N. R., The Reticuloendothelial System in Health and Disease (Eds. H. Friedman, M. R. Escobar and S. M. Reichard ), Plenum Press, New York, Vol. A (1976) 412.Google Scholar
  6. 6.
    Di Luzio, N. R., Kuppfer Cells and Other Liver Sinusoidal Cells (Eds. E. Wisse and D. L. Knook ), Elsevier/North Holland, Amsterdam (1977) 397.Google Scholar
  7. 7.
    Gillet, J., Jacques, P. J. and Herman, F., this volume.Google Scholar
  8. 8.
    Glovsky, M. M., Di Luzio, N. R., Alenty, A. and Ghekiere, L. R., J. Reticuloendothelial Soc., 20 (1976) 54a.Google Scholar
  9. 9.
    Holmes, I. B. and Hilson, G. R. F., Proc. Soc. Exp. Biol. Med., 145 (1974) 1395.PubMedGoogle Scholar
  10. 10.
    Komatsu, N., Sakai, S., Saito, G., Kikumoto, S. and Kimura, N., United States Patents, application 378054 (1976).Google Scholar
  11. 11.
    Nguyen, B. T. and Stadtsbaeder, S., this volume.Google Scholar
  12. 12.
    Rees, R. J. W. and Valentine, R. C., Intern. J. Lepr., 30 (1962) 1.Google Scholar
  13. 13.
    Sansarricq, H., Experientia, 33 (1977) 114.CrossRefGoogle Scholar
  14. 14.
    Shepard, C. C., J. Exp. Med., 112 (1960) 445.PubMedCrossRefGoogle Scholar
  15. 15.
    Shepard, C. C., Intern. J. Lepr., 35 (1967) 429.Google Scholar
  16. 16.
    Shepard, C. C., Ellard, G. A., Levy, L., de Araujo-Opromolla, V., Pattyn, S. R., Peters, J. H., Rees, R. J. W. and Waters, M. F. R., Bull. World Health Org., 53 (1976) 425.Google Scholar
  17. 17.
    Song, M., Demoulin-Brahy, L. and Jacques, P. J., Current Chemotherapy, Am. Soc. Microbiol., Washington (1978) 234.Google Scholar
  18. 18.
    Stevens, M. M., Stevens, P., Cook, J. A., Ichinose, H. and DiLuzio, N. R., J. Reticuloendothelial Soc., 20 (1976) 66a.Google Scholar
  19. 19.
    Whistler, R. L., Bushway, A. A., Singh, P. P., Nakahara, W. and Tokuzen, R., Adv. Carbohydr. Chem. Biochem., 32 (1976) 235.CrossRefGoogle Scholar
  20. 20.
    Williams, D., Cook, J. A. and Di Luzio, N. R., J. Reticuloendthelial Soc., (1977) In press.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. Delville
    • 1
  • P. J. Jacques
    • 1
  1. 1.School of Public HealthUniversité Catholique de LouvainBrusselsBelgium

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