Role of the RES in Lead Salt Sensitization to Endotoxin Shock
Lead salts when administered to experimental animals in doses which by themselves are quite innocuous render the lead-treated subject markedly sensitive to lethal endotoxicosis as well as other forms of shock (2, 9, 11). A role for the RES in lead-sensitization to endotoxin shock was suggested by the ability of lead acetate to depress the intravascular clearance of colloidal agents (2, 5). Since previous studies from our laboratory have suggested a glucoregulatory role for the RES in resistance to endotoxin shock (1, 5, 6, 7, 8, 9, 10), the present study evaluated the effect of lead-induced depression of the RES on glucose homeostasis and insulin dynamics.
KeywordsSodium Acetate Glucose Oxidation Lead Acetate Serum Insulin Level Hepatic Gluconeogenesis
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