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Role of the RES in Lead Salt Sensitization to Endotoxin Shock

  • J. P. Filkins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)

Abstract

Lead salts when administered to experimental animals in doses which by themselves are quite innocuous render the lead-treated subject markedly sensitive to lethal endotoxicosis as well as other forms of shock (2, 9, 11). A role for the RES in lead-sensitization to endotoxin shock was suggested by the ability of lead acetate to depress the intravascular clearance of colloidal agents (2, 5). Since previous studies from our laboratory have suggested a glucoregulatory role for the RES in resistance to endotoxin shock (1, 5, 6, 7, 8, 9, 10), the present study evaluated the effect of lead-induced depression of the RES on glucose homeostasis and insulin dynamics.

Keywords

Sodium Acetate Glucose Oxidation Lead Acetate Serum Insulin Level Hepatic Gluconeogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. P. Filkins
    • 1
  1. 1.Stritch School of MedicineLoyola University of ChicagoChicagoUSA

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