Effect of Proteinases on EA (IgG)-Binding Receptors of Rat Macrophages

  • G. Boltz-Nitulescu
  • O. Förster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 121B)


Reports about the proteinase sensitivity of macrophage receptors for IgG (Fc-receptor) are equivocal. Sorkin (10) studying binding of cytophilic antibody to rabbit splenic macrophages found the binding diminished after treatment with proteolytic enzymes. Other authors, however, found an enhanced (1, 2) or unchanged (4, 7, 9) Fc-receptor activity after proteinase treatment of macrophages from various species. On mouse macrophages 2 different Fc-receptors for rabbit IgG were reported, 1 for aggregated IgG being trypsin resistant, another for monomeric mouse IgG2a being sensitive to digestion by trypsin (3, 11).


Proteolytic Enzyme Proteinase Treatment Rosette Form Cell Pronase Digestion Proteinase Sensitivity 


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • G. Boltz-Nitulescu
    • 1
  • O. Förster
    • 1
  1. 1.Institute of General and Experimental PathologyUniversity of ViennaViennaAustria

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