Far and Near Ultraviolet Radiation Products and Their Repair
The chronological history of our knowledge of the molecular mechanisms and the biochemical events involved in the processes of repair of radiation damage is short, but the thinking that led to these recent exciting developments is as old as the fields of radiobiology and photobiology. Ever since different survival curves were obtained for mutant strains of the same microbial cells, the search has begun for the reasons which could explain this intrinsic difference in behaviour towards radiation. When thymidine dimers were identified as the major ultraviolet radiation product responsible for cell death, a breakthrough was reached by the discovery of the excision repair system (1,2,3) which gave a logical explanation to the differences in radio and photosensitivity of wild type “resistant” cells vs mutant “sensitive” cells, followed by developments with mammalian cells which led to our better understanding of many phenomena and diseases such as autoimmune diseases in which genetic damage is involved and DNA repair is impaired.
KeywordsStrand Break Excision Repair Single Strand Break Thymine Dimer Radiation Product
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