UV Photobiology: Postreplication Repair
We have discussed two repair modes: 1) photoreactivation, in which dimers are reversed in DNA; and 2) excision repair, in which lesions are removed from the DNA. What happens if it is time for the cell to synthesize a whole new copy of DNA before the lesions are reversed or removed? One might image a number of scenarios. 1) The DNA repair enzymes may stop at the damage and never start again. 2) The DNA repair enzymes might go on inserting a few bases, not necessarily the right ones, and then copy as usual. 3) Finally, the DNA repair enzymes might fall off the DNA and resume synthesis further downstream.
KeywordsExcision Repair Action Spectrum Xeroderma Pigmentosum Pyrimidine Dimer Cold Spring Harbor Symposium
Unable to display preview. Download preview PDF.
- 4.Lehmann, A. R., Kirk-Bell, S., Arlett, C. F. Paterson, M. C., Lohmann, P. H. M., de Weerd-Kastelein, E. A., and Bootsma, D., Proc. Nat. Acad. Sci. USA 72, 219–223.Google Scholar