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Time-Resolved Fluorescence Studies on Drug Binding Sites

  • David Phillips
  • Kenneth P. Ghiggino
  • Anthony G. Lee
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 25)

Abstract

Fluorescence spectroscopic techniques have been widely used in the past to obtain information about simple lipid bilayers and purified lipid-protein complexes. The same techniques have also been used to study intact biological membranes but the results of such studies have been much more difficult to interpret, simply because the membrane is a highly heterogeneous structure. In general a single composite spectrum is obtained either from all components of the membrane or from probe molecules dissolved in a variety of sites in the membrane when excited with continuous wave radiation.

Keywords

Fluorescence Lifetime Fluorescence Decay Microsomal Membrane Dual Exponential Function Intense Light Pulse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • David Phillips
    • 1
  • Kenneth P. Ghiggino
    • 1
  • Anthony G. Lee
    • 1
  1. 1.Chemistry DepartmentThe UniversitySouthamptonUK

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