How Basic Knowledge of the Cell Cycle Has Helped Us Treat Cancer Patients
While empiricism has, in the past, prominently influenced therapeutic research generally and therapeutic research in cancer specifically, knowledge derived from basic and bridging sciences is increasingly impacting on such research. For cancer, such sciences include particularly pharmacology, immunology, and cytokinetics. The purpose of this presentation is to describe the impact of cytokinetics on therapeutic research in cancer. Increasing knowledge of the cytokinetic behavior of tumors and target normal tissues, and of the effect of various chemotherapeutic agents on aspects of the cell cycle have provided increasingly important therapeutic leads for extrapolation to the clinic. With advances in methodology, it has become increasingly possible to conduct selected cytokinetic studies in parallel with clinical trials.
KeywordsAntitumor Agent Tritiated Thymidine Growth Fraction Mitotic Cycle Nitrogen Mustard
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