• James A. Robb
  • Clifford W. Bond
Part of the Comprehensive Virology book series (CV, volume 14)


Coronaviruses are widespread in nature, but relatively little attention has been given to them. They are pathogenic, enveloped RNA viruses whose large, single—stranded, nonsegmented genome is of a positive polarity. They cause a broad spectrum of disease in their natural hosts, including man, primarily by a cytocidal virus—cell interaction. The structure of the virion, the molecular mechanisms of their multiplication strategy, and their pathogenesis are just beginning to receive the attention they deserve.


Bovine Viral Diarrhea Virus Infectious Bronchitis Virus Infectious Bursal Disease Virus Mouse Hepatitis Virus Feline Infectious Peritonitis 


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  1. Alexander, D. J., and Chettle, N. J., 1977, Procedures for the haemagglutination and the haemagglutination inhibition tests for avian infectious bronchitis virus, Avian Pathol. 6:9.PubMedGoogle Scholar
  2. Alexander, D. J., and Gough, R. E., 1977, Isolation of avian infectious bronchitis virus from experimentally infected chickens, Res. Vet. Sci. 23:344.PubMedGoogle Scholar
  3. Alexander, D. J., Gough, R. E., and Pattison, M., 1978, A long-term study of the pathogenesis of infection of chickens with three strains of avian infectious bron chitis virus, Res. Vet. Sci. 24(2):228.PubMedGoogle Scholar
  4. Alexander, D. J., Bracewell, C. D., and Gough, R. E., 1976, Preliminary evaluation of the haemagglutination and haemagglutination inhibition tests for avaian infectious bronchitis virus, Avian Pathol. 5:125.PubMedGoogle Scholar
  5. Allen, J. G., 1977, Congenital cerebellar hypoplasia in jersey calves, Aust. Vet. J. 53:173.PubMedGoogle Scholar
  6. Apostolov, K., Spasic, P., and Bojanic, N., 1977a, Comparative ultrastructural studies on endemic (Balkan) nephropathy and chicken embryo nephritis caused by infectious bronchitis virus. I. Endemic (Balkan) nephropathy, Acta Med. Jug. 31:189.Google Scholar
  7. Apostolov, K., Spasic, P., and Alexander, D. J., 1977b ,Comparative ultrastructural studies on endemic (Balkan) nephropathy and chicken embryo nephritis caused by infectious bronchitis virus. II. Chick embryo nephritis, Acta Med. Jug. 31:205.Google Scholar
  8. Atkins, G. J., Samuels, J., and Kennedy, S. I. T., 1974, Isolation and preliminary characterization of temperature-sensitive mutants of Sindbis virus strain AR 339, J. Gen. Virol. 25:371.PubMedGoogle Scholar
  9. Bailey, O. T., Pappenheimer, A. M., Sargent, F., Cheever, M. D., and Daniels, J. B., 1949, A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. II. Pathology, J. Exp. Med. 90:195.PubMedGoogle Scholar
  10. Berry, D. M., and Almeida, J. D., 1968, The morphological and biological effects of various antisera on avian infectious bronchitis virus, J. Gen. Virol. 3:97.PubMedGoogle Scholar
  11. Bhatt, P. N., and Jacoby, R. O., 1977, Experimental infection of adult axenic rats with Parker’s rat Coronavirus, Arch. Virol. 54:345.PubMedGoogle Scholar
  12. Bingham, R. W., 1975, The polypeptide composition of avian infectious bronchitis virus, Arch. Virol. 49:207.PubMedGoogle Scholar
  13. Bingham, R. W., and Almeida, J. D., 1977, Studies on the structure of a coronavirus-avian infectious bronchitis virus, J. Gen. Virol. 36:495.PubMedGoogle Scholar
  14. Binn, L. N., Lazar, E. C., Keenan, K. P., Huxsoll, D. L., Marchwicki, R. H., and Strano, A. J., 1974, Recovery and characterization of a Coronavirus from military dogs with diarrhea, Proc. Annu. Meet. U.S. Anim. Health Assoc. 78:359.PubMedGoogle Scholar
  15. Bond, C. W., and Robb, J. A., 1979, Pathogenic murine coronaviruses. II. Characterization of virus-specific intracellular proteins: JHMV and A59V, Virology 94:371.PubMedGoogle Scholar
  16. Broderson, J. R., Murphy, F. A., and Hierholzer, J. C., 1976, Lethal enteritis in infant mice caused by mouse hepatitis virus, Lab. Anim. Sci. 26:824.PubMedGoogle Scholar
  17. Brown, T. T., DeLahunta, A., Bistner, S. I., Scott, F. W., and McEntee, K., 1974, Pathogenetic studies of infection of the bovine fetus with bovine viral diarrhea virus. I. Cerebellular atrophy, Vet. Pathol. 11:486.PubMedGoogle Scholar
  18. Caul, E. O., and Clarke, S. K. R., 1975, Coronavirus propagated from patient with non-bacterial gasteroenteritis, Lancet 2:7942.Google Scholar
  19. Caul, E. O., and Egglestone, S. I., 1977, Further studies on human enteric coronaviruses, Arch. Virol. 54:107.PubMedGoogle Scholar
  20. Chasey, D., and Alexander, D. J., 1976, Morphogenesis of avian infectious bronchitis virus in primary chick kidney cells, Arch. Virol. 52:101.PubMedGoogle Scholar
  21. Chasey, D., and Lucas, M., 1977, A bovine Coronavirus identified by thin-section electron microscopy, Vet. Rev. 100:530.Google Scholar
  22. Cheever, F. S., Daniels, J. B., Pappenheimer, A. M., and Bailey, O. T., 1949, A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. I. Isolation and biological properties of the virus, J. Exp. Med. 90:181.PubMedGoogle Scholar
  23. Collins, M. S., Alexander, D. J., and Harkness, J. W., 1976, Heterogeneity of infectious bronchitis virus grown in eggs, Arch. Virol. 50:55.PubMedGoogle Scholar
  24. Cook, J. K. A., Darbyshire, J. H., and Peters, R. W., 1976, Growth kinetic studies of avian infectious bronchitis virus in tracheal organ cultures, Res. Vet. Sci. 20:348.PubMedGoogle Scholar
  25. Cowen, B. S., and Hitchner, S. B., 1975, Serotyping of avian infectious bronchitis viruses by the virus-neutralization test, A vian Dis. 19:583.Google Scholar
  26. Cowen, B. S., Hitchner, S. B., and Lucio, B., 1971, Characterization of a new infectious bronchitis virus isolate. I. Serological and pathogenicity studies of Clark 333, Avian Dis. 15:517.Google Scholar
  27. Darbyshire, J. H., Cook, J. K. A., and Peters, R. W., 1975, Comparative growth kinetic studies on avian infectious bronchitis virus in different systems, J. Comp. Pathol. 85:623.PubMedGoogle Scholar
  28. Darbyshire, J. H., Cook, J. K. A., and Peters, R. W., 1976, Organ culture studies on the efficiency of infection of chicken tissues with avian infectious bronchitis virus, Br. J. Exp. Pathol. 57:443.PubMedGoogle Scholar
  29. Deshmukh, D. R., Sautter, J. H., Patel, B. L., and Pomeroy, B. S., 1976, Histopathology of fasting and bluecomb disease in turkey poults and embryos experi mentally infected with bluecomb disease Coronavirus, Avian Dis. 20:631.PubMedGoogle Scholar
  30. Doughri, A. M., and Storz, J., 1977, Light and ultrastructural pathologic changes in intestinal Coronavirus infection of newborn calves, Zentralbl. Veterinaermed. 24:367.Google Scholar
  31. Doughri, A. M., Storz, J., Hajer, I., and Fernando, H. S., 1976, Morphology and morphogenesis of a Coronavirus infecting intestinal epithelial cells of newborn calves, Exp. Mol. Pathol. 25:355.PubMedGoogle Scholar
  32. Dupuy, J. M., Levey-Leblond, E., and Le Prevost, C., 1975, Immunopathology of mouse hepatitis virus type 3 infection. II. Effect of immunosuppression in resistant mice, J. Immunol. 114:226.PubMedGoogle Scholar
  33. Dutta, S. K., 1974, Morphological changes in chicken tracheas and tracheal organ cultures infected with avian infectious bronchitis virus studied in scanning electron microscope, Avian Dis. 19:429.Google Scholar
  34. Egan, J. A., and Tannock, G. A., 1978, A comparative evaluation of chicken embryo tracheal organ cultures for the assay of avian infectious bronchitis virus, J. Biol. Stand. 6:205.PubMedGoogle Scholar
  35. England, J. J., Frye, C. S., and Enright, E. A., 1975, Negative contrast electron microscopic diagnosis of viruses of neonatal calf diarrhea, Cornell Vet. 66:172.Google Scholar
  36. Fabricant, J., and Levine, P. P., 1951, The persistence of infectious bronchitis virus in eggs and tracheal exudates of infected chickens, Cornell Vet. 41:240.PubMedGoogle Scholar
  37. Fleissner, E., 1971, Chromatographic separation and antigenic analysis of proteins of the oncornaviruses, J. Virol. 8:778.PubMedGoogle Scholar
  38. Flewett, T. H., and Boxall, E., 1976, The hunt for viruses in infections of the alimentary system: An immunoelectron-microscopical approach. Clin. Gastroenterol. 5:359.PubMedGoogle Scholar
  39. Fox, J. G., Murphy, J. C., and Igras, V. E., 1977, Adverse effects of mouse hepatitis virus on ascites myeloma passage in the BALBJ/cJ mouse, Lab. Anim.Sci. 27: 173.PubMedGoogle Scholar
  40. Frederick, G. T., and Bohl, E. H., 1976, Local and systemic cell-mediated immunity against transmissible gastroenteritis, an intestinal viral infection of swine, J. Immunol. 116:1000.Google Scholar
  41. Fujiwara, K., Tamura, T., Hirano, N., and Takenaka, S., 1975, Implication pancréatique chez la souris infectée avec le virus de I’hépatite murine, C. R. S. Soc. Biol. 169:477.Google Scholar
  42. Fujiwara, K., Tamura, T., Taguchi, F., Machii, K., and Suzuki, K., 1976, Immunisation de la Souris nude contre le virus de l’hépatite murine par transfert de lymphocytes sensibilisés, C. R. Soc. Biol. 170:509.Google Scholar
  43. Gard, G. P., Acland, H. M., and Plant, J. W., 1976, A mucosal disease virus as a cause of abortion, hairy birth coat and unthriftiness in sheep. 2. Observation on lambs surviving for longer than seven days, Aust. Vet. J. 52:64.Google Scholar
  44. Garwes, D. J., and Pocock, D. H., 1975, The polypeptide structure of transmissible gastroenteritis virus, J. Gen. Virol. 29:25.PubMedGoogle Scholar
  45. Garwes, D. J., Pocock, D. H., and Wijaszka, T. M., 1975, Identification of heat-dissociable RNA complexes in two porcine coronaviruses, Nature (London) 257:508.Google Scholar
  46. Garwes, D. J., Pocock, D. H., and Pike, B. V., 1976, Isolation of subviral components from transmissable gastroenteritis virus, J. Gen. Virol. 32:283.PubMedGoogle Scholar
  47. Giambrone, J. J., Eidson, C. S., and Kleven, S. H., 1977, Effect of infectious bursal disease on the response of chickens to Mycoplasma synoviae ,Newcastle disease virus, and infectious bronchitis virus, Am. J. Vet. Res. 38:251.Google Scholar
  48. Gonder, E., Patel, B. L., and Pomeroy, B. S., 1976, Scanning electron, light, and immunofluorescent microscopy of coronaviral enteritis of turkeys (bluecomb), Am. J. Vet.Res.37:1435.PubMedGoogle Scholar
  49. Goto, N., Hirano, N., Aiuchi, M., Hayashi, T., and Fujiwara, K., 1977, Nasoenceph-alopathy of mice infected intranasally with a mouse hepatitis virus, JHM strain, Jpn. J. Exp. Med. 47:59.Google Scholar
  50. Greig, A. S., and Bouillant, A. M. P., 1977, Binding effects of cancanavalin A on a Coronavirus, Can. J. Comp. Med. 41:122.PubMedGoogle Scholar
  51. Greig, A. S., Johnson, C. M., and Bouillant, A. M. P., 1971, Encephalomyelitis of swine caused by a haemagglutinating virus, Res. Vet. Sci. 12:305.PubMedGoogle Scholar
  52. Gump, D. W., Phillips, C. A., Forsythe, B. R., Mcintosh, K., Lamborn, K. R., and Stouch, W. H., 1976, Am. Rev. Res. Dis. 113:465.Google Scholar
  53. Hafez, S. M., Liess, B., and Frey, H.-R., 1976, Studies on the natural occurrence of neutralizing antibodies against six strains of bovine viral diarrhea virus in field sera of cattle, Zentralbl. Veterinaermed. 23:669.Google Scholar
  54. Herndon, R. M., Griffin, D. E., McCormick, U., and Weiner, L. P., 1975, Mouse hepatitis virus-induced recurrent demyelination. A preliminary report, Arch. Neurol. 32:32.PubMedGoogle Scholar
  55. Hidalgo, H., and Raggi, L. G., 1976, Identification of seven isolants of infectious bronchitis virus by interference with the B-l isolant of Newcastle disease virus, Avian Dis. 20:167.PubMedGoogle Scholar
  56. Hierholzer, J. C., 1976, Purification and biophysical properties of human Coronavirus 229E, Virology 75:155.PubMedGoogle Scholar
  57. Hierholzer, J. C., and Tannock, G. A., 1977, Quantitation of antibody to nonhemag-glutinating viruses by single radial hemolysis: Serological test for human coronaviruses,J. Clin. Microbiol. 5:613.PubMedGoogle Scholar
  58. Hierholzer, J. C., Palmer, E. L., Whitfield, S. G., Kaye, H. S., and Dowdle, W. R., 1972, Protein composition of Coronavirus OC43, Virology 48:516.PubMedGoogle Scholar
  59. Hirano, N., Fujiwara, K., Hino, S., and Matumoto, M., 1974, Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture, Archiv. Gesamti. Virusforsch. 44:298.Google Scholar
  60. Hirano, N., Takenaka, S., and Fujiwara, K., 1975a, Pathogenicity of mouse hepatitis virus for mice depending upon host age and route of infection, Jpn. J. Exp. Med. 45:285.PubMedGoogle Scholar
  61. Hirano, N., Tamura, T., Taguchi, F., Ueda, K., and Fujiwara, K., 1975b, Isolation of low-virulent mouse hepatitis virus from nude mice with wasting syndrome and hepatitis, Jpn. J. Exp. Med. 45:429.PubMedGoogle Scholar
  62. Hirano, N., Fujiwara, K., and Matumoto, M., 1976, Mouse hepatitis virus (MHV-2) Plaque assay and propagation in Mouse cell line DBT cells, Jpn. J. Microbiol. 20:219.PubMedGoogle Scholar
  63. Holmes, K. V., and Allen, R., 1977, Chronic infection in vitro with the corona virus MHV, Abstr. Annu. Meet. Am. Soc. Microbiol. ISSN 0067–2777:345.Google Scholar
  64. Horzinek, M. C., Osterhaus, A. D. M. E., and Ellens, D. J., 1977, Feline infectious peritonitis virus, Zentralbl. Veterinaermed. Reihe B 24:398.Google Scholar
  65. Huang, A. S., and Baltimore, D., 1977, Defective interfering animal viruses, in: Comprehensive Virology ,Vol. 10 (H. Fraenkel-Conrat and R. R. Wagner, eds.), pp. 73–116, Plenum, New York.Google Scholar
  66. Hunter, T., and Garrells, J. I., 1977, Characterization of the mRNAs for ; ,ß and r actin, Cell 12:767.Google Scholar
  67. Inaba, Y., Sato, K., Kurogi, H., Takahashi, E., Ito, Y., Omori, T., Goto, Y., and Matumoto, M., 1976, Replication of bovine Coronavirus in cell line BEK-1 culture, Arch. Virol. 50:339.PubMedGoogle Scholar
  68. Ishii, A., Yago, A., Nariuchi, H., Shirasaka, A., Wada, Y., and Matushasi, T., 1974, Some aspects on the transmission of hepatitis B antigen; model experiments by mosquitoes with murine hepatitis virus, Jpn. J. Exp. Med. 44:495.PubMedGoogle Scholar
  69. Jackson, G. G., and Muldoon, R. L., 1975, Viruses Causing Common Respiratory Infections in Man ,pp. 132–141, University of Chicago Press, Chicago.Google Scholar
  70. Jacoby, R. O., Bhatt, P. N., and Jonas, A. M., 1975, Pathogenesis of sialodacryoadenitis in gnotobiotic rats, Vet. Pathol. 12:196.PubMedGoogle Scholar
  71. Kapikian, A. Z., 1975, The coronaviruses, Dev. Biol. Stand. 28:42.PubMedGoogle Scholar
  72. Kaye, H. S., Yarbrough, W. B., Reed, C. J., Harrison, A. K., 1977, Antigenic relationship between human Coronavirus strain OC43 and hemagglutinating encephalomyelitis virus strain 67N of swine: Antibody responses in human and animal sera, J. Infect. Dis. 135:201.PubMedGoogle Scholar
  73. Keenan, K. P., Jervis, H. R., Marchwicki, R. H., and Binn, L. N., 1976, Intestinal infection of neonatal dogs with canine Coronavirus 1–71: Studies by virologic, histologic, histochemical and immunofluorescent techniques, Am. J. Vet. Res. 37: 247.Google Scholar
  74. Kemeny, L. J., 1976, Antibody response in pigs inoculated with transmissible gastroenteritis virus and cross reactions among ten isolates, Can J. Comp. Med. 40:209.PubMedGoogle Scholar
  75. Kemeny, L. J., and Woods, R. D., 1977, Quantitative transmissible gastroenteritis virus shedding patterns in lactating sows, Am. J. Vet. Res. 38:307.PubMedGoogle Scholar
  76. Kemeny, L. J., Wiltsey, V. L, and Riley, J. L., 1974, Upper respiratory infection of lactating sows with transmissible gastroenteritis virus following contact exposure to infected piglets, Cornell Vet. 65:352.Google Scholar
  77. Kennedy, D. A., and Johnson-Lussenberg, 1975/1976, Isolation and morphology of the internal component of human Coronavirus, strain 229E, Intervirology 6:197.PubMedGoogle Scholar
  78. Kerzner, B., Kelley, M. H., Gall, D. G., Butler, D. G., and Hamilton, J. R., 1977, Transmissible gastroenteritis: Sodium transport and the intestinal epithelium during the course of viral enteritis, Gastroenterology 72:457.PubMedGoogle Scholar
  79. King, A. A., and Harkness, J. W., 1975, Viral contamination of foetal bovine serum, Vet. Rec. 97:16.PubMedGoogle Scholar
  80. Kiuchi, Y., Yamanaka, H., Miyamoto, S., and Fujiwara, K., 1974, Susceptibility to mouse hepatitis virus of mice from infected and non-infected breeding colonies, Exp. Anim. 24:25.Google Scholar
  81. Krum, S., Johnson, K., and Wilson, J., 1975, Hydrocephalus associated with the nonef-fusive form of feline infectious peritonitis, J. Am. Vet. Med. Assoc. 167:746.PubMedGoogle Scholar
  82. Lai, M. M. C., and Stohlman, S. A., 1978, The RNA of mouse hepatitis virus, J. Virol. 26:236.PubMedGoogle Scholar
  83. Lai, Y.-L., Jacoby, R. O., Bhatt, P. N., and Jonas, A. M., 1976, Keratoconjunctivitis associated with sialodacryoadenitis in rats, Invest. Ophthalmol. 15:538.PubMedGoogle Scholar
  84. Lampert, P. W., 1978, Autoimmune and virus-induced demyelinating diseases, Am. J. Pathol. 91:176.PubMedGoogle Scholar
  85. Lampert, P. W., Sims, J. K., and Kniazeff, A. J., 1973, Mechanism of demyelination in JHMV virus encephalomyelitis. Electron microscopic studies, Acta Neuropathol. 24:76.PubMedGoogle Scholar
  86. LePrévost, C., Levy-Leblond, E., Virelizier, J. L., and Dupuy, J. M., 1975a, Immunopathology of mouse hepatitis virus type 3 infection. 1. Role of humoral and cell-mediated immunity in resistance mechanisms, J. Immunol. 114:221.PubMedGoogle Scholar
  87. LePrévost, C., Virelizier, J. L., and Dupuy, J. M., 1975b, Immunopathology of mouse hepatitis virus type 3 infection, III. Clinical and virologic observation of a persistent viral infection, J. Immunol. 115:640.Google Scholar
  88. Lomniczi, B., 1977, Biological properties of avian Coronavirus RNA, J. Gen. Virol. 36:531.PubMedGoogle Scholar
  89. Lomniczi, B., and Kennedy, I., 1977, Genome of infectious bronchitis virus, J. Virol. 24:99.PubMedGoogle Scholar
  90. Lucas, A., Flintoff, W., Anderson, R., Percy, D., Coulter, M., and Dales, S., 1977, In vivo and in vitro models of demyelinating diseases: Tropism of the JHM strain of murine hepatitis virus for cells of glial origin, Cell 12:553.PubMedGoogle Scholar
  91. Lucio, B., and Hitchner, S. T., 1970, Differentiation and detection of infectious bronchitis virus subtypes by immunofluorescence, Avian Dis. 14:9.PubMedGoogle Scholar
  92. MacNaughton, M. R., and Madge, M. H., 1977a, The polypeptide composition of avian infectious bronchitis virus, Arch. Virol. 55:47.PubMedGoogle Scholar
  93. MacNaughton, M. R., and Madge, M. H., 1977b, The characterization of the virion RNA of avian infectious bronchitis virus, FEBS Lett. 77:311.PubMedGoogle Scholar
  94. MacNaughton, M. R., Madge, M. H., Davies, H. A., and Dourmashkin, R. R., 1977, Polypeptides of the surface projections and the ribonucleoprotein of avian infectious bronchitis virus, J. Virol. 24:821.PubMedGoogle Scholar
  95. Matsuno, S., Inouye, S., and Kono, R., 1977, Plaque assay of neonatal calf diarrhea virus and the neutralizing antibody in human sera, J. Clin. Microbiol. 5:1.PubMedGoogle Scholar
  96. McClung, H. J., Butler, D. G., Kerzner, B., Gall, D. G., and Hamilton, J. R., 1976, Transmissible gastroenteritis. Mucosal ion transport in acute viral enteritis, Gastroen terology 70:1091.Google Scholar
  97. Mcintosh, K., 1974, Coronaviruses: A comparative review, Curr. Top. Microbiol. Immunol. 63:86.Google Scholar
  98. Mcintosh, K., Chao, R. K., Krause, H. E., Wasil, R., Mocega, H., and Mufson, M., 1974, Coronavirus infection in acute lower respiratory tract disease of infants, J. Infect. Dis. 130:502.PubMedGoogle Scholar
  99. Mengeling, W. L., and Cutlip, R. C., 1976, Pathogenicity of field isolants of hemag-glutinating encephalomyelitis virus for neonatal pigs, J. Am. Vet. Med. Assoc. 168:236.PubMedGoogle Scholar
  100. Mishra, N. K., and Ryan, W. L., 1973, Ribonucleic acid synthesis in porcine cell cultures infected with transmissable gastroenteritis virus, Am. J. Vet. Res. 34:185.PubMedGoogle Scholar
  101. Monto, A. S., 1974, Coronaviruses, Yale J. Biol. Med. 47:234.Google Scholar
  102. Monto, A. S., 1976, Coronaviruses, in: Viral Infections of Humans (A. S. Evans, ed.), pp. 127–141, Plenum, New York.Google Scholar
  103. Monto, A. S., and Rhodes, L. M., 1977, Detection of Coronavirus infection of man by immunofluorescence, Proc. Soc. Exp. Biol. Med. 155:143.PubMedGoogle Scholar
  104. Moore, B., Lee, P., Hewish, M., Dixon, B., and Mukherjee, T., 1977, Coronaviruses in training centre for intellectually retarded, Lancet 1:261.PubMedGoogle Scholar
  105. Morin, M., Morehouse, L. G., Solorzano, R. F., and Olson, L. D., 1973, Transmissible gastroenteritis in feeder swine: Clinical immunofluorescence and histopathological observations, Can. J. Comp. Med. 37:239.PubMedGoogle Scholar
  106. Morin, M., Laiviere S., and Lallier, R., 1976, Pathological and microbiological observations made on spontaneous cases of acute neonatal calf diarrhea, Can. J. Comp. Med. 40:228.PubMedGoogle Scholar
  107. Namiki, M., Takayama, H., and Fujiwara, K., 1977, Viral growth in splenic megakaryocytes of mice experimentally infected with mouse hepatitis virus, MHV-2, Jpn. J. Exp. Med. 47:41.Google Scholar
  108. Naqi, S. A., Panigrahy, B., and Hall, C. F., 1975, Purification and concentration of viruses associated with transmissible (coronaviral) enteritis of turkeys (bluecomb), Am. J. Vet. Res. 36:548.PubMedGoogle Scholar
  109. Nelson, J. B., 1952, Acute hepatitis associated with mouse leukemia. I. Pathological features and transmission of the disease, J. Exp. Med. 96:293.PubMedGoogle Scholar
  110. Norman, J. O., McClurkin, A. W., and Bachrach, H. L., 1968, Infectious nucleic acid from a transmissable agent causing gastroenteritis in pigs, J. Comp. Pathol. 78:227.PubMedGoogle Scholar
  111. Oth, D., Achille, E., Levy-LeBlond, E., and Dupuy, J. M., 1976, H-2 Influence on the chronic disease due to mouse hepatitis virus type 3, Folia Biol. 22:409.Google Scholar
  112. Patel, B. L., Pomeroy, B. S., Gonder, E., and Cronkite, C. E., 1976, Indirect fluorescent antibody tests for the diagnosis of coronaviral enteritis of turkeys (bluecomb), Am. J. Vet. Res. 31:1111.Google Scholar
  113. Patel, B. L., Gonder, E., and Pomeroy, B. S., 1977, Detection of turkey coronaviral enteritis (bluecomb) in field epiornithics, using the direct and indirect fluorescent antibody tests, Am. J. Vet. Res. 38:1407.PubMedGoogle Scholar
  114. Patterson, S., and Bingham, R. W., 1976, Electron microscope observations on the entry of avian infectious bronchitis virus into susceptible cells, Arch. Virol. 52:191.PubMedGoogle Scholar
  115. Pedersen, N. C., 1976, Morphologic and physical characteristics of feline infectious peritonitis virus and its growth in autochthonous peritoneal cell cultures, Am. J. Vet. Res. 37:567.PubMedGoogle Scholar
  116. Pfefferkorn, E. R., and Shapiro, D., 1974, Reproduction of togaviruses, in: Comprehensive Virology (H. Fraenkel-Conrat and R. R. Wagner, eds.), pp. 171–230, Plenum, New York.Google Scholar
  117. Piazza, M., 1969, Experimental Viral Hepatitis ,Thomas, Springfield, 111.Google Scholar
  118. Pike, B. V., and Garwes, D. J., 1977, Lipids of transmissible gastroenteritis virus and their relation to those of two different host cells, J. Gen. Virol. 34:531.PubMedGoogle Scholar
  119. Plant, J. W., Acland, H. M., and Gard, G. P., 1976, A mucosal disease virus as a cause of abortion hairy birth coat and unthriftiness in sheep. I. Infection of pregnant ewes and observations on aborted foetuses and lambs dying before one week of age, Aust. Vet. J. 52:57.PubMedGoogle Scholar
  120. Pocock, D. H., and Garwes, D. H., 1977, The polypeptides of hemagglutinating encephalomyelitis virus and isolated subviral particles, J. Gen. Virol. 37:487.Google Scholar
  121. Powell, H. C., and Lampert, P. W., 1975, Oligodendrocytes and their myelinplasma membrane connections in JHM mouse hepatitis virus encephalomyelitis, Lab. Invest. 33:440.PubMedGoogle Scholar
  122. Purcell, D. A., Tham, V. L., and Surman, P. G., 1976, The histopathology of infectious bronchitis in fowls infected with a nephrotropic T strain of virus, Aust. Vet. J. 52:85.PubMedGoogle Scholar
  123. Reed, J. M., Schiff, L. J., Shefner, A. M., and Poiley, S. M., 1975, Murine virus sus ceptibility of cell cultures of mouse, rat, hamster, monkey and human origin, Lab. Anim. Sci. 25:420.PubMedGoogle Scholar
  124. Reynolds, D. J., Garwes, D. J., and Gaskell, C. J., 1977, Detection of transmissible gastroenteritis virus neutralising antibody in cats, Arch. Virol. 55:77.PubMedGoogle Scholar
  125. Rinaldo, C. R., Isackson, D. W., Overall, J. C., Glasgow, L. A., Brown, T. T., Bistner, S. I., Gillespie, J. H., and Scott, F. W., 1976, Fetal and adult bovine interferon production during bovine virual diarrhea virus infection, Infect. Immun. 14:660.PubMedGoogle Scholar
  126. Riski, H., Hovi, T., Väänänen, P., and Penttinen, K., 1977, Antibodies to human Coronavirus OC43 measured by radial haemolysis in gel. Scand. J. Infect. Dis. 9:75.Google Scholar
  127. Robb, J. A., 1977, Virus cell interactions: A classification for virus-caused human disease, Prog. Med. Virol. 23:51.PubMedGoogle Scholar
  128. Robb, J. A., and Bond, C. W., 1979a, Pathogenic murine coronaviruses. I. Characterization of biological behavior in vitro and virus-specific intracellular RNA of strongly neurotropic JHMV and weakly neurotropic A59V viruses, Virology 94:352.PubMedGoogle Scholar
  129. Robb, J. A., Bond, C. W., and Leibowitz, J., 19796, Pathogenic murine coronaviruses. III. Biological and biochemical characterization of temperature-sensitive mutants of 5HMV, Virology 94:385.PubMedGoogle Scholar
  130. Sabesin, S. M., 1972, Isolation of a latent murine hepatitis virus from cultured mouse liver cells, Am. J. Gastroenterol. 58:259.PubMedGoogle Scholar
  131. Saif, L. J., Bohl, E. H., Kohler, E. M., and Hughes, J. H., 1977, Immune electron microscopy of transmissible gastroenteritis virus and rotavirus (reovirus-like agent) of swine, Am. J. Vet. Res. 38:13.PubMedGoogle Scholar
  132. Schochetman, G., Stevens, R. H., and Simpson, R. W., 1977, Presence of infectious polyadenylated RNA in the Coronavirus avian bronchitis virus, Virology 77:772.PubMedGoogle Scholar
  133. Sebesteny, A., and Hill, A. C., 1974, Hepatitis and brain lesions due to mouse hepatitis virus accompanied by wasting in nude mice, Lab. Anim. 8:317.PubMedGoogle Scholar
  134. Sharpee, R. L., Mebus, C. A., and Bass, E. P., 1976, Characterization of a calf diarrheal Coronavirus, Am. J. Vet. Res. 37:1031.PubMedGoogle Scholar
  135. Shope, R. E., Muscoplat, C. C., Chen, A. W., and Johnson, D. W., 1976, Mechanism of protection from primary bovine viral diarrhea virus infection. I. The effects of dexamethasone, Can. J. Comp. Med. 40:355.PubMedGoogle Scholar
  136. Smith, G. C., Kalter, S. S., Heberling, R. L., and Helmke, R. J., 1975/1976, Particles morphologically resembling mouse hepatitis virus in nude mouse uterus, Intervirology 6:90.Google Scholar
  137. Snowdon, W. A., Parsonson, I. M., and Broun, M. L., 1975, The reaction of pregnant ewes to inoculation with mucosal disease virus of bovine origin, J. Comp. Pathol. 85:241.PubMedGoogle Scholar
  138. Sprino, P. H., Morilla, A., and Ristic, M., 1976, Intestinal immune response of feeder pigs to infection with transmissible gastroenteritis, Am. J. Vet. Res. 37:171.PubMedGoogle Scholar
  139. Stark, S. L., Fernelius, A. L., Booth, G. D., and Lambert, G., 1974, Transmissible gastroenteritis (TGE) of swine: Effect of age of swine testes cell culture monolayers on plaque assays of TGE virus, Can. J. Comp. Med. 39:466.Google Scholar
  140. Stohlman, S. A., and Frelinger, J. A., 1978, Resistance to fatal central nervous system disease by mouse hepatitis virus, strain JHM. I. Genetic analysis, Immunogenetics 6:277.Google Scholar
  141. Stohlman, S. A., and Weiner, L. P., 1978, Stability of neurotropic mouse hepatitis virus (JHM strain) during chronic infection of neuroblastoma cells, Arch. Virol. 57:53.PubMedGoogle Scholar
  142. Stone, S. S., Jensen, M. T., Kemeny, L. J., and Wiltsey, L., 1976, Chromatographic separation of gram quantities of immunoglobulins from porcine colostrum against transmissible gastroenteritis virus, J. Immunol. Methods 11:333.PubMedGoogle Scholar
  143. Stone, S. S., Kemeny, L. J., Woods, R. D., and Jensen, M. T., 1977, Efficacy of isolated colostral IgA, IgG, and IgM(A) to protect neonatal pigs against the Coronavirus of transmissible gastroenteritis, Am. J. Vet. Res. 38:1285.PubMedGoogle Scholar
  144. Sturman, L. S., 1977, Characterization of a Coronavirus. I. Structural proteins: Effects of preparative conditions on the migration of protein in Polyacrylamide gels, Virology 77:637.PubMedGoogle Scholar
  145. Sturman, L. S., and Holmes, K. V., 1977, Characterization of a Coronavirus. II. Glycoproteins of the viral envelope: Tryptic peptide analysis, Virology 77:650.PubMedGoogle Scholar
  146. Sturman, L. S., and Takemoto, K. K., 1972, Enhanced growth of a murine Coronavirus in transformed mouse cells, Infect. Immun. 6:501.PubMedGoogle Scholar
  147. Taguchi, F., Hirano, N., Kiuchi, Y., and Fujiwara, K., 1976, Difference in response to mouse hepatitis virus among susceptible mouse strains, Jpn. J. Microbiol. 20:293.PubMedGoogle Scholar
  148. Taguchi, F., Aiuchi, M., and Fujiwara, K., 1977, Age-dependent response of mice to a mouse hepatitis virus, MHV-S, Jpn. J. Exp. Med. 47:109.Google Scholar
  149. Takayama, J., and Kirn, A., 1976, An improved method for titration of mouse hepatitis virus type 3 in a mouse cell culture, Arch. Virol. 52:347.PubMedGoogle Scholar
  150. Takeuchi, A., Binn, L. N., Jervis, H. R., Keenan, K., Hildebrandt, P. K., Valas, R. B., and Bland, F. F., 1976, Electron microscope study of experimental enteric infection in neonatal dogs with a canine Coronavirus, Lab. Invest. 34:539.PubMedGoogle Scholar
  151. Tamura, T., Ueda, K., Hirano, N., and Fujiwara, K., 1976, Response of nude mice to a mouse hepatitis virus isolated from a wasting nude mouse, Jpn. J. Exp. Med. 46:19.PubMedGoogle Scholar
  152. Tamura, T., Taguchi, I., Ueda, K., and Fujiwara, K., 1977, Persistent infection with mouse hepatitis virus of low virulence in nude mice, Microbiol. Immunol. 21:683.PubMedGoogle Scholar
  153. Tanaka, R., Iwasaki, Y., and Koprowski, H., J., 1976, Intracisternal virus-like particles in brain of a multiple sclerosis patient, J. Neurol. Sci. 28:121.PubMedGoogle Scholar
  154. Tannock, G. A., 1973, The nucleic acid of infectious bronchitis virus, Arch. Gesamte Virusforsch. 43:259.PubMedGoogle Scholar
  155. Tannock, G. A., and Hierholzer, J. C., 1977, The RNA of human Coronavirus OC43, Virology 78:500.PubMedGoogle Scholar
  156. Tannock, G. A., and Hierholzer, J. C., 1978, Presence of genomic polyadenylate and absence of detectable virion transcriptase in human Coronavirus OC43, J. Gen. Virol. 39:29.PubMedGoogle Scholar
  157. Thomas, F. C., and Dulac, G. C., 1976, Transmissible gastroenteritis virus: Plaques and a plaque neutralization test, Can. J. Comp. Med. 40:171.PubMedGoogle Scholar
  158. Thornton, D. H., and Muskett, J. C., 1975, Effect of infectious bronchitis vaccination on the performance of live Newcastle disease vaccine, Vet. Rec. 96:467.PubMedGoogle Scholar
  159. Timoney, J. F., 1976, Feline infectious peritonitis, Vet. Clin. N. Am. 6:391.Google Scholar
  160. Traavik, T., Mehl, R., and Kjeldsberg, E., 1977, Runde Virus, a coronavirus-like agent associated with seabirds and ticks, Arch. Virol. 55:25.PubMedGoogle Scholar
  161. Tyrrell, D. A. J., Almeida, J. D., Cunningham, C. H., Dowdle, W. R., Hofstad, M. S., Mcintosh, K., Tajima, M., Zakstelskaya, L. Y., Esterday, B. C., Kapikian, A., and Bingham, R. W., 1975, Coronaviridae, Intervirology 5:76.PubMedGoogle Scholar
  162. Underdahl, N. R., Mebus, C. A., Stair, E. L., Rhodes, M. B., McGill, L. D., and Twiehaus, M. J., 1974, Isolation of transmissible gastroenteritis virus from lungs of market-weight swine, Am. J. Vet. Res. 35:1209.PubMedGoogle Scholar
  163. Underdahl, N. R., Melbus, C. A., and Torres-Medina, A., 1975, Recovery of transmissible gastroenteritis virus from chronically infected experimental pigs, Am. J. Vet. Res. 36:1473.PubMedGoogle Scholar
  164. Virelizier, J. L., and Gresser, I., 1978, Role of interferon in the pathogenesis of viral diseases of mice as demonstrated by the use of anti-interferon serum. IV. Protective role in mouse hepatitis virus type 3 infection of susceptible and resistant strains of mice, J. Immunol. 120:1616.PubMedGoogle Scholar
  165. Virelizier, J. L., Dayan, A. D., and Allison, A. C., 1975, Neuropathological effects of persistent infection of mice by mouse hepatitis virus, Infect. Immun. 12:1127.PubMedGoogle Scholar
  166. Virelizier, J. L., Virelizier, A. M., and Allison, A. C., 1976. The role of circulating interferon in the modifications of immune responsiveness by mouse hepatitis virus (MHV-3),J. Immunol. 117:748.PubMedGoogle Scholar
  167. Ward, J. M., Collins, M. J., and Parker, J. C., 1977, Naturally occurring mouse hepatitis virus infection in the nude mouse, Lab. Anim. Sci. 27:372.PubMedGoogle Scholar
  168. Watkins, H., Reeve, P., and Alexander, D. J., 1975, The ribonucleic acid of infectious bronchitis virus, Arch. Virol. 47:279.PubMedGoogle Scholar
  169. Weiner, L. P., 1973, Pathogenesis of demyelination induced by a mouse hepatitis virus (JHM virus), Arch. Neurol. 28:298.PubMedGoogle Scholar
  170. Weisbroth, S. H., and Peress, N., 1977, Ophthalmic lesions and dacryoadenitis: A naturally occurring aspect of sialodacryoadenitis virus infection of the laboratory rat, Lab. Anim. Sci. 27:466.PubMedGoogle Scholar
  171. Weiser, W., and Bang, F. B., 1976, Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages. J. Exp. Med. 143:690.PubMedGoogle Scholar
  172. Weiser, W. Y., and Bang, F. B., 1977, Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus, J. Exp. Med. 146:24.Google Scholar
  173. Weiser, W., Vellisto, I., and Bang, F. B., 1976, Congenic strains of mice susceptible and resistant to mouse hepatitis virus, Proc. Soc. Exp. Biol. Med. 152:499.PubMedGoogle Scholar
  174. Werdin, R. E., Sorensen, D. K., and Stewart, W. C., 1976, Porcine encephalomyelitis caused by hemagglutinating encephalomyelitis virus, J. Am. Vet. Med. Assoc. 168:240.PubMedGoogle Scholar
  175. Whitmore, H. L., and Archbald, L. F., 1977, Demonstration and quantitation of immunoglobulins in bovine serum, follicular fluid, and uterine and vaginal secre-Google Scholar
  176. tions with reference to bovine viral diarrhea and infectious bovine rhinotrachietis, Am. J. Vet. Res. 38:455.Google Scholar
  177. Woods, R. D., 1977, Leukocyte migration-inhibition procedure for transmissible gastroenteritis viral antigens, Am. J. Vet. Res. 38:1267.PubMedGoogle Scholar
  178. Wooley, R. E., and Brown, J., 1977, Correlation of cytopathic effect, fluorescent-antibody microneutralization, and plaque reduction test results for determining avian infectious bronchitis virus antibodies, J. Clin. Microbiol. 5:361.PubMedGoogle Scholar
  179. Yogo, Y., Hirano, N., Hino, S., Shibuta, H., and Matumoto, M., 1977, Polyadenylate in the virion RNA of mouse hepatitis virus, J. Biochem. 82:1103.PubMedGoogle Scholar
  180. Zuckerman, A. J., 1978, A new human hepatitis virus, Nature (London) 271:113.Google Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • James A. Robb
    • 1
  • Clifford W. Bond
    • 1
  1. 1.Department of PathologyUniversity of California, San DiegoLa JollaUSA

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