Temperature and Pressure Dependence of the Hydrophobic Interactions
The study of the temperature and the pressure dependence of the HI is of interest for several reasons. The first is its relevance to biological processes. It is well known that proteins undergo a process of denaturation as the temperature is raised. This process disrupts their normal function and therefore threatens the entire activity, or life, of any biological system. There are indications, as will be demonstrated in Section 5.4, that the strength of the HI increases with a rise in the temperature, at least in the range of temperatures of biological interest. It seems, therefore, that this behavior of the HI contributes to the thermal stability of proteins against the tendency of denaturation.
KeywordsPartition Function Methylene Blue Pressure Dependence Free Energy Change Pressure Coefficient
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