Very Dilute Solutions and Hydrophobic Interaction
In the previous chapter we noted that there are essentially two different concepts which are discussed in the literature under the same term, hydrophobic interaction (or hydrophobic bond). One is represented by the standard free energy of transfer of a solute S between water and some other nonaqueous solvent, and it measures the relative tendency of the solute S to prefer one environment over the other. The second measures the tendency of two (or more) solute molecules to aggregate in aqueous solutions. Both quantities have a common feature, i.e., they express some kind of “phobia” for the aqueous environment. However, they are quite different, and in general one cannot infer anything about one quantity from the other. In fact we shall see in Section 3.4 that in some cases they provide an apparently contradictory result as to the degree of “phobia” for two solvents.
KeywordsFree Energy Hydrophobic Interaction Fixed Position Solute Molecule Standard Free Energy
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