Introduction and Fundamental Equations

  • Arieh Ben-Naim


The term “hydrophobic interaction” (HI) has been used in connection with several closely related phenomena. It is difficult to trace the origin of this term [or of its predecessor—the “hydrophobic bond”—apparently first coined by Kauzmann (1954, 1959)], but it is quite clear that this concept has been used in the biochemical literature to describe a variety of biochemical processes, including conformational changes of a biopolymer, the binding of a substrate to an enzyme, the association of subunits to form a multisubunit enzyme, and processes involving high levels of aggregation such as the formation of biological membranes and the organization of biological molecules to form a functional unit in a living system.


Free Energy Hydrophobic Interaction Free Energy Change Fixed Position Fundamental Equation 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Arieh Ben-Naim
    • 1
  1. 1.Department of Physical ChemistryThe Hebrew University of JerusalemJerusalemIsrael

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