Metabolic Factors Affecting Brain Cyclic Nucleotides

  • L. Volicer
  • R. Mirin
  • R. Meichner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 116)


Initial investigations of cyclic nucleotides indi cated that they act as second messengers mediating hormonal stimulation (ROBISON et al., 1971). More recently it was recognized that in the central nervous system cyclic nucleotides might play a more general role as modulators of nerve transmission (IVERSEN et al., 1975; MCILWAIN, 1976). Thus changes of cyclic nucleotide levels might significantly affect the function of specific brain structures. In this paper we would like to demonstrate that some drugs affect cyclic nucleotide levels not by changes of neurotransmitter release but by their effects on brain metabolism.


Cyclic Nucleotide Guanylate Cyclase Ethanol Oxidation Acoustic Startle Response Ethanol Administration 


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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • L. Volicer
    • 1
  • R. Mirin
    • 1
  • R. Meichner
    • 1
  1. 1.Department of PharmacologyBoston University School of MedicineBostonUSA

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