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Neurotransmitters and Neuromodulators and their Mediation by Cyclic Nucleotides

  • G. R. Siggins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 116)

Abstract

In a symposium devoted to the discussion of modula tors, mediators and specifiers in brain, it seems propitious first to address the issue of what these agents are and what criteria may be developed to define them. This task seems particularly timely now because of the burgeoning number of substances found in brain which seem not to strictly fit our preconceived notions of a neurotransmitter. Therefore, after developing criteria for neurotransmitters, mediators and modulators, I will provide examples of substances that could satisfy the criteria for these classifications, with special emphasis on norepinephrine (NE), cyclic AMP and the opioid peptides.

Keywords

Purkinje Cell Locus Coeruleus Cyclic Nucleotide Opioid Peptide Membrane Conductance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • G. R. Siggins
    • 1
  1. 1.The Salk InstituteLa JollaUSA

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