Do Behaviorally Active Polypeptide Hormones Act at Crucial “Command” Sites or at Many Sites, from “Command” Down to “Final Common Paths”?
Mechanisms by which polypeptides interact with neu rons in higher animals may have their resolution suggested by analogy with results in simpler systems, such as in cell culture systems (BARKER, et al., 1978), in isolated parts of the nervous system, such as in brain slices (BLOOM, et al., 1978), or in nearly intact, but simpler, nervous systems of invertebrates (see below). For questions concerning organizational aspects of the nervous system, cell culture and brain slice preparations lack the requisite organization to provide an appropriate analogy, but invertebrate systems offer technically accessible but nevertheless sufficiently structured preparations for studying these problems. For example, one question of interest to us is whether polypeptide hormones which affect behavior exert their effects by acting at a few crucial “command” sites in the nervous system or whether they interact at many levels, from “command” down to “final common paths” residing in motor neurons and their target muscles.
KeywordsMotor Neuron Cerebral Ganglion Medial Lobe Command Neuron Abdominal Ganglion
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