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Measurement of β-Endorphin-Like Immunoreactivity in CSF and Plasma of Neuropsychiatric Patients

  • H. M. Emrich
  • V. Höllt
  • W. Kissling
  • M. Fischler
  • H. Heinemann
  • D. v. Zerssen
  • A. Herz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 116)

Abstract

The hypothesis of a possible role of endorphins in the pathogenesis of psychoses has its origin in two types of observations. Firstly from the euphorogenic action of opiates and, possibly, endorphins (KLINE & LEHMANN, 1978) in normal subjects, leading to the idea that endogenous opioids may be responsible for mood changes in affective psychoses (TERENIUS et al., 1977) and, secondly, from the fact that certain partial opiate agonists, such as cyclozocine and nalorphine, induce hallucinations and derealization experience in healthy volunteers which can be immediately reversed by the specific opiate antagonist naloxone (JASINSKI et al., 1967). From this latter finding it was concluded that productive symptoms (e.g. hallucinations and delusions) in schizophrenic patients might be induced by abnormally functioning opioids with a spectrum of action similar to that of partial opiate agonists (summary: EMRICH, 197 8; SNYDER, 1978; TERENIUS, 197 8; VEREBEY et al., 1978).

Keywords

Schizophrenic Patient Silicic Acid Chronic Case Mental Health Research Endogenous Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • H. M. Emrich
    • 1
  • V. Höllt
    • 1
  • W. Kissling
    • 1
  • M. Fischler
    • 1
  • H. Heinemann
    • 2
  • D. v. Zerssen
    • 1
  • A. Herz
    • 1
  1. 1.Max-Planck-Institut für PsychiatrieMunichGermany
  2. 2.Bezirkskrankenhaus KaufbeurenGermany

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