The Obesity of Middle Age: A Common Variety of Cushing’s Syndrome Due to a Chronic Increase in Adrenocorticotrophin (ACTH) and Beta-Endorphin Activity
In 1977, the select committee on nutrition and human needs of the United States Senate held hearings on obesity (HEARINGS, 1977). They concluded that obesity is a killer disease affecting at least 30 million Americans in 197 7. One-half of these people are obese to a degree that shortens life. The frequency of obesity increases substantially with age. One-third of American men and 40% of American women between the ages of 4 0 and 49 are obese. The obese have a substantially reduced life expectancy, a high incidence of diabetes mellitus, gall bladder problems, a high incidence of cardiovascular disease , thin skin that tears easily, a greater likelihood to die from anesthesia, greater susceptibility to infection, greater chances of phlebitis, and a higher likelihood of gout. Many obese individuals have a history of an unsuccessful life struggle to reduce their body weight. Over 10 billion dollars a year are spent in this country for obesity treatments that fail. The few individuals who have some success at weight loss often regain the lost weight. Those rare individuals that succeed in maintaining the weight loss have a life-long battle to prevent relapse of the obese condition (HEARINGS, 197 7).
KeywordsObesity Osteoporosis Adenoma Morphine Serotonin
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- ALBRIGHT, F. (1942–43) Cushing’s syndrome. Harvey Lect. 38, 123.Google Scholar
- CUSHING, H. (1932) The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull. Johns Hopkins Hosp. 50, 137.Google Scholar
- Hearings before the select committee on nutrition and human needs of the United States Senate, 95th Congress, first session, Feb. 1 and 2, 1977, part 2, obesity. Diet related to killer diseases, II. U.S. Government Printing Office, Washington, 1977.Google Scholar
- KERWICK, A. (1965) Adiposity. In Handbook of Physiology , section 5, Adipose tissue, pp. 617–624. American Physiological Society.Google Scholar
- MARGULES, D.L. (1978) Molecular theory of obesity, sterility and other behavioral and endocrine problems in genetically obese mice (ob/ob). Neurosciences and Biobehavioral Reviews 2(4), in press.Google Scholar
- SCHILLINGER, E. & GERHARDS, E. (1974) Effects of pituitary hormones and corticosterone on lipolysis in hypophysectomized rats. Acta Endocrinologia 77, 502–508.Google Scholar