Endorphins and Clinical Pain, an Overview

  • L. Terenius
  • A. Wahlström
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 116)


The existence of selective opiate receptors and the finding that stimulation produced analgesia could be re versed by the selective opiate antagonist, naloxone, led to the prediction and detection of endorphins. It was subsequently found that the endorphins belonged to the growing family of brain peptides. These peptides are present in specific neurons of the CNS, suggesting that they are neuromessengers1. The fact that the pharmacology of opiates had a long history and was being studied extensively at the time of discovery, facilitated a rapid development of knowledge about endorphins. Many classically trained pharmacologists moved into a new field, that of brain peptides. The discovery of endorphins is therefore a very important landmark in the development of the neurosciences and consequently, brain peptides in general are now the focus of contemporary brain research.


Pain Syndrome Opioid Peptide Clinical Pain Pain Reaction Receptor Occupation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • L. Terenius
    • 1
  • A. Wahlström
    • 1
  1. 1.Department of PharmacologyUniversity of UppsalaUppsalaSweden

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