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Polarisability Anisotropy as an Indicator of the Effects of Aminoglycoside Antibiotics on Sensitive, Dependent and Resistant Strains of E.coli

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Electro-Optics and Dielectrics of Macromolecules and Colloids

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Abstract

Using high frequency, low amplitude pulsed electric fields, the anisotropy of the electrical polarisability (△α) of E.coli bacteria may be evaluated from scattered light intensity changes. △α has been found to be very sensitive to the addition of antibiotics to aqueous E.coli suspensions. With increasing antibiotic concentration △α decreases in a manner reminiscent of an adsorption isotherm. Illustrative data on the interaction of aminoglycoside antibiotics with a sensitive, a dependent and two resistant strains of E.coli K 12 is presented and discussed.

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Author information

Authors and Affiliations

  1. Electro-Optics Group, Physics Department, Brunel University, Uxbridge, Middlesex, UK

    V. J. Morris & B. R. Jennings

  2. Department of Microbiology, Queen’s Medical Centre, University Hospital, University of Nottingham, Nottingham, UK

    N. J. Pearson & F. O’Grady

Authors
  1. V. J. Morris
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  2. B. R. Jennings
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  3. N. J. Pearson
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  4. F. O’Grady
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Editor information

Editors and Affiliations

  1. Brunel University, Uxbridge, England

    Barry R. Jennings

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© 1979 Plenum Press, New York

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Morris, V.J., Jennings, B.R., Pearson, N.J., O’Grady, F. (1979). Polarisability Anisotropy as an Indicator of the Effects of Aminoglycoside Antibiotics on Sensitive, Dependent and Resistant Strains of E.coli. In: Jennings, B.R. (eds) Electro-Optics and Dielectrics of Macromolecules and Colloids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3497-2_19

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  • DOI: https://doi.org/10.1007/978-1-4684-3497-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3499-6

  • Online ISBN: 978-1-4684-3497-2

  • eBook Packages: Springer Book Archive

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