Mutual Impedivity Spectrometry and the Feasibility of its Incorporation into Tissue-Diagnostic Anatomical Reconstitution and Multivariate Time-Coherent Physiological Measurements

  • Otto H. Schmitt


Measurement of the electrical impedance of biological tissue in vitro and in vivo has entered prominently into three classes of biological research and biomedical applications. Pioneered some half century ago by Fricke (1922, 1924, 1925A, 1925B) and perfected by his followers Cole and Curtis (1934, 1950), measurements of the electrical self-impedance of a variety of cell and tissue systems were made across the audio, lower radio, and even into the medium to high radio frequencies. These data were examined most commonly in the more familiar impedance domain comprised of resistance and reactance rather than in the electrically equivalent admittance domain of conductance and susceptance, thus giving, unintentionally, an implicit preference to serially organized circuit models.


Guard Ring Local Impedivity Squid Giant Axon Transfer Impedance Mutual IMPEDIVITY 
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  1. Almasi, J. J, and Schmitt, O. H., “Basic Technology of Voluntary Cardiorespiratory Synchronization in Electrocardiology, ” IEEE Trans. Biomed. Engrg., BME-21, 264–273 (1974).Google Scholar
  2. Cole, K. S., and Curtis, H. J., “Bioelectricity: Electric Physiology,” in Medical Physics Vol. II ( Glasser, O., ed. ) (1950), pp. 82–90.Google Scholar
  3. Cole, K. S., and Curtis, H. J., “Electrical Impedance of the Squid Giant Axon During Activity,” in Medical Physics, Vol. II (Glasser, O., ed.) (1950), pp. 82–90.Google Scholar
  4. Cole, K. S., and Curtis, H. J., “Electrical Impedance of the Squid Giant Axon During Activity, ” J. Gen. Physiol. 22: 649 (1939).CrossRefGoogle Scholar
  5. Conference on Bioelectrical Impedance S. Markovich (ed.), Ann. N.Y. Acad. Sci. 170/2 (1970).Google Scholar
  6. Curtis, H. J., and Cole, K. S., “Transverse Electric Impedance of the Squid Giant Axon,” J. Gen. Physiol. 21: 757 (1938).CrossRefGoogle Scholar
  7. Fricke, H., “The Electric Capacity of Cell Suspensions,” Physical Review 21: 708–709 (1923).Google Scholar
  8. Fricke, H., “The Electric Capacity of Suspensions with Special Reference to Blood,” J. General Physiology 9:137–152 (1925B).Google Scholar
  9. Fricke, H., “A Mathematical Treatment of the Electric Conductivity and Capacity of Diverse Systems. I. The Electric Conductivity of a Suspension of Homogeneous Spheroids,” Physical Review 24: 575–587 (1924).CrossRefGoogle Scholar
  10. Fricke, H., “A Mathematical Treatment of the Electric Conductivity and Capacity of Diverse Systems. II. The Capacity of a Suspension of Conducting Spheroids Currounded by a Non-Conducting Membrane for a Current of Low Frequency,” Physical Review 26:678–681 (1925A).Google Scholar
  11. Geselowitz, D. B., and Schmitt, O. H., ’’Electrocardiography,“ in Biological Engineering ( Schwan, H. P., ed.) McGraw-Hill (1969), pp. 333–390.Google Scholar
  12. Khalafalla, A. S., and Schmitt, O. H., “Z-Differential Leads,” Medical Research Engineering 9 (4): 11–17 (1970).Google Scholar
  13. Kubicek, W. G., Karnegis, J. N., Patterson, R. P., Witsoe, D. A., and Mattson, R. H., “Development and Evaluation of an Impedance Cardiac Output System,” Aerospace Medicine 37: 1208–1212 (1966).Google Scholar
  14. Kubicek, W. G., et al., “The Minnesota Impedance Cardiograph-Theory and Applications,” Biomed. Eng. 9: 410–416 (1974).Google Scholar
  15. National Academy of Sciences, Biologic Effects of Electric and Magnetic Fields Associated with Proposed Project Seafarer Report of the Committee on Biosphere Effects of ExtremelyLow-Frequency Radiation, Division of Medical Sciences, Assembly of Life Sciences, National Research Council (1977), pp. 107–128.Google Scholar
  16. National Institutes of Health Progress Reports HE00513 and HE07575.Google Scholar
  17. Nyboer, J., Electrical Impedance Plethysmography Springfield, Ill., Charles C. Thomas, 1939.Google Scholar
  18. Schmitt, O. H., “The Biophysical Basis of Electrocardiography,” Proc. 1st Nat’l. Biophysics Conf., Columbus, Ohio (March 4–6, 1957), New Haven, Yale University Press (1959), pp. 510–562.Google Scholar
  19. Schmitt, O. H., “Cathode Ray Presentation of Three-Dimensional Data,” J. App. Physiol. 18: 819–829 (1947).CrossRefGoogle Scholar
  20. Schmitt, O. H., “Lead Vectors and Transfer Impedance,” Annals of the N. Y. Acad. Sci. 65: 1092–1109 (1957).CrossRefGoogle Scholar
  21. Schmitt, O. H. H., “Phase Space Display of Vectorially-Resolved Electrocardiograms,” Digest of Technical Papers, 12th An. Con. Elec. Techniques in Med. and Biol. (Nov. 1959).Google Scholar
  22. Schmitt, O. H., “Some Basics of ELF Fields and Their Biosphere Effects,” in The Physical Basis of Electromagnetic Inter- actions with Biological Systems (Taylor, L. S., and Cheung, A. Y., eds.), pp. 71–74.Google Scholar
  23. Schmitt, O. H., “Some Biophysical Bases of Electrocardiographic Analysis,” in Differentiation Between Normal and Abnormal in Electrocardiography (Simonson, E., ed. ), C. V. Mosby Co. (1961), pp. 281–284.Google Scholar
  24. Schmitt, O. H., et al., Sources and Surface Representation of the Cardiac Electric Field 7th International Colloquium Vectorcardiographicum, Slovak Academy of Sciences, Bratislava, Swets and Zeitlinger, Amsterdam (1970).Google Scholar
  25. Schmitt, O. H., and Simonson, E., “The Present Status of Vector-cardiography,” A.M.A. Archives of Internal Medicine 96: 574–590 (1955).CrossRefGoogle Scholar
  26. Schwan, H. P., “Die Elektrischen Eigenschaften von Muskelgewebe Bei Niederfrequenz,” Zeits. Naturforschung 9b: 245–251 (1954).Google Scholar
  27. Schwan, H. P., Electrical Impedance of the Human Body U.S. Naval Weapons Laboratory, Technical Report TR-2199, Dahlgren, Va. (August 1968).Google Scholar
  28. Schwan, H. P. P., “Electrical Properties of Body Tissues and Impedance Plethysmography,” IRE Trans. Med. Elec. PGME-3: (1955).Google Scholar
  29. Schwan, H. P., “Electrical Properties of Tissue and Cell Suspensions,” Advan. Biol. Med. Physics 5: 147–209 (1957).Google Scholar
  30. Schwan, H. P., and Cole, K. S., “Bioelectricity: Alternating Current Admittance of Cells and Tissues,” in Medical Physics, Vol. 3 ( Glasser, O., ed. ) (1960), pp. 52–56.Google Scholar
  31. Schwan, H. P., and Kay, C. F., “The Conductivity of Living Tissues,” Ann. N. Y. Acad. Sci. 65 (6): 1007–1013 (1957).CrossRefGoogle Scholar
  32. Schwan, H. P., and Maczuk, J., “Electrical Relaxation Phenomena of Biological Cells and Colloidal Particles at Low Frequencies,” Proc. 1st Nat’l. Biophysics Conf., Columbus, Ohio (March 4–6, 1957), New Haven, Yale University Press (1959), pp. 348–355.Google Scholar
  33. Schwan, H. P., Schwartz, G., Maczuk, J., and Pauly, H., “On the Low-Frequency Dielectric Dispersion of Colloidal Particles in Electrolyte Solution,” J. Phys. Chem. 66: 2626–2635 (1962).CrossRefGoogle Scholar

Copyright information

© United Engineering Trustees 1979

Authors and Affiliations

  • Otto H. Schmitt
    • 1
  1. 1.University of MinnesotaMinneapolisUSA

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