Event Related Potential Investigations in Children at High Risk for Schizophrenia

  • David Friedman
  • Herbert G. VaughanJr.
  • L. Erlenmeyer-Kimling
Part of the NATO Conference Series book series (NATOCS, volume 9)


The search for the antecedents of schizophrenia has recently been advanced by the introduction of research in which individuals who are known to be at high statistical risk for schizophrenia are studied prospectively before the onset of disturbances in functioning (Pearson and Kley, 1957; Mednick and McNeill, 1968; Garmezy and Streitman, 1974; Erlenmeyer-Kimling, 1975). Children of schizophrenic parents are chosen as the high risk subjects; if one parent is schizophrenic, some ten to fifteen percent of the children are expected to develop the psychosis in adolescence or adulthood, and if both parents are schizophrenic, the risk increases 36–40 percent (Zerbin-Rüdin, 1967; Erlenmeyer-Kimling, 1968; 1978). The high risk children are compared with children of normal parents for whom the risk estimate is only about one percent, on variables of interest to the investigating team, and, because the comparison is longitudinal, the development of the disorder can be followed. Thus, this research approach eliminates many of the biases prevalent when information is obtained from retrospective reports, although other types of problems may be inherent in the high risk design.


Evoke Potential Contingent Negative Variation High Risk Child Late Positive Component Late Positive Complex 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • David Friedman
    • 1
  • Herbert G. VaughanJr.
    • 1
  • L. Erlenmeyer-Kimling
    • 1
  1. 1.New York State Psychiatric InstituteNew York CityUSA

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