Application of Somatosensory Event Related Potentials to Experimental Pain and the Pharmacology of Analgesia

  • Monte S. Buchsbaum
  • Glenn C. Davis
Part of the NATO Conference Series book series (NATOCS, volume 9)


There is increasing evidence that many neurotransmitter systems may be involved in pain appreciation including cholinergic agents, endorphins, biogenic amines and others (Mayer and Price, 1976). This suggests that there are multiple mediators of pain appreciation, each involving a possibly distinct neural pathway. Event related potentials may offer a means of separating distinct pain modulation processes in phamacological experiments in man.


Stimulus Intensity Pain Sensitivity Evoke Potential Somatosensory Evoke Potential N120 Component 


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  1. Buchsbaum, M.S., Davis, G.C. and Bunney, W.E., Jr. Naloxone alters pain perception and somatosensory evoked potentials in normal subjects. Nature, 1977, 270, 620–622.PubMedCrossRefGoogle Scholar
  2. Buchsbaum, M.S. Self-regulation of stimulus intensity: Augmenting/ reducing and the average evoked response. In G.E. Schwartz and D. Shapiro (Eds.), Consciousness and Self-Regulation, New York: Plenum Press, 1976.Google Scholar
  3. Buchsbaum, M.S. Average evoked response augmenting/reducing in schizophrenia and affective disorders. In D.X. Freedman (Ed.), The Biology of the Major Psychoses, A Comparative Analysis, New York: Raven Press, 1975.Google Scholar
  4. Chapman, C. R., Murphy, T.M. and Butler, S. Analgesic strength of 33 percent nitrous oxide: A signal detection theory evaluation. Science, 1973, 179, 1246–1248.PubMedCrossRefGoogle Scholar
  5. Clark, W.C. and Goodman, J. Effects of suggestion on d’ and cx for pain detection and pain tolerance. J. Abnorm. Psychol., 1974, 83, 364–372.PubMedCrossRefGoogle Scholar
  6. Coppola, R. Isolating low frequency activity in EEG spectrum analysis. Electroenceph. Clin. Neurophysiol., in press.Google Scholar
  7. Goff, G.D., Matsumiya, Y., Allison, T. and Goff, W.R. The scalp topography of human somatosensory and auditory evoked potentials. Electroenceph. Clin. Neurophysiol., 1977, 42, 57–76.PubMedCrossRefGoogle Scholar
  8. Lavine, R., Buchsbaum, M.S. and Poncy, M. Auditory analgesia: Somatosensory evoked response and siabjective pain rating. Psycho- physiol., 1976, 13, 140–148.Google Scholar
  9. Levy, R. and Mushin, J. The somatosensory evoked response in patients with hysterical anaesthesia. U. Psychosom. Res., 1973, 17, 81–84.CrossRefGoogle Scholar
  10. Lykken, D.T., Macindoe, I. and Teilegen, A. Perception: Autonomic response to shock as a function of predictability in time and locus. Psychophysiol., 1972, 9, 318–333.CrossRefGoogle Scholar
  11. Mayer, D.J. and Price, D.D. Central nervous system mechanism of analgesia. Pain, 1976, 2, 379–404.PubMedCrossRefGoogle Scholar
  12. Mushin, J. and Levy, R. Averaged evoked response in patients with psychogenic pain. Psychol. Med., 1974, 4, 19–27.PubMedCrossRefGoogle Scholar
  13. Satran, R. and Goldstein, M. Pain perception: Modification of threshold of intolerance and cortical potentials by cutaneous stimulation. Science, 1973, 180, 1201–1202.PubMedCrossRefGoogle Scholar
  14. Sitaram, N., Buchsbaum, M.S. and Gillin, J.C. Physostigmine analgesia and somatosensory evoked responses in man. Europ. J. Pharm., 1977, 42, 285–290.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Monte S. Buchsbaum
    • 1
  • Glenn C. Davis
    • 1
  1. 1.Biological Psychiatry BranchNational Institute of Mental HealthBethesdaUSA

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