Serum Bilirubin Levels in Full-Term and Premature Macaca nemestrina
Neonatal jaundice is one of the most common problems among human neonates. It is estimated that 25–50% of all normal newborn infants exhibit clinical jaundice during the first week of life (Maisels, 1975). The large majority of these infants demonstrate what is called “physiological jaundice” with bilirubin concentrations reaching 5–7 mg/100 ml. Others, including the majority of premature infants, show a prolonged elevation in bilirubin concentrations (hyperbilirubinemia) with serum bilirubin levels reaching well over 20 mg/100 ml. The association between prolonged elevations in serum bilirubin levels and the occurrence of kernicterus is well documented (Hsia, Allen, Gellis, and Diamond, 1952; Perlstein, 1960). However, it is still unclear what level of bilirubin constitutes a potential risk for developing neurological or behavioral abnormalities owing to bilirubin intoxication. Several studies have found a positive relation between small increases in bilirubin concentrations and subsequent neurological and behavioral impairments (O’Dell, Storey, and Rosenberg, 1970; Hardy and Peeples, 1971). According to one study, this relation becomes critical at a concentration of 16–19 mg/100 ml (Boggs, Hardy, and Fraiser, 1967). That the potential for behavioral deficits due to bilirubin intoxication increases on a continuum with increases in bilirubin concentrations must be further considered and investigated. Factors relating to increased susceptibility to neurological or behavioral abnormalities at relatively low concentrations of bilirubin (prematurity, Hyaline Membrane Disease) must also be elucidated.
KeywordsPremature Infant Serum Bilirubin Serum Bilirubin Level Bilirubin Concentration Serum Albumin Concentration
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- Beamer, T., Blakley, G., Fahrenbruch, C., and Sackett, G. Estimation of gestational age and prediction of parturition date from fetal radiographs in M. nemestrina. In preparation.Google Scholar
- Hardy, J., and Peeples, M. Serum bilirubin levels in newborn infants. Distributions and associations with neurological abnormalities during the first year of life. J.hns Hopkins Med. J. 128: 265, 1971.Google Scholar
- Maisels, M. Neonatal Jaundice. Pp. 335–378 in: Neonatology, Pathophysiology and Management of the Newborn, G. Avery (Ed.), Philadelphia: J. B. Lippencott, Co., 1975.Google Scholar
- Morrow, A. and Terry, M. Liver function tests in blood of nonhuman primates tabulated from the literature. A publication of the Primate Information Center, Regional Primate Research Center at the University of Washington, 1972.Google Scholar
- Perlstein, M. The clinical syndrome of kernicterus. Pediatric Clinics of North America. Neuropediatrics 7: 665, 1960.Google Scholar
- Robinson, F. and Ziegler, R. Clinical laboratory data derived from 102 Macaca mulatta. Lab. anim. Care 18: 50–57, 1968.Google Scholar
- Siegel, S. Nonparametric Statistics for the Behavioral Sciences. New York: McGraw-Hill Book Company, 1956.Google Scholar