Suppression of Ovarian Function by LHRH and Its Analogues in Pregnant Rats
The chronic administration of large doses of LHRH and its analogues to rats from Days 1 through 7 of pregnancy delayed ovum implantation (1,2). The ovaries of pregnant rats treated with an LHRH analogue were significantly smaller than the ovaries of control intact rats; the corpora lutea were small and no large antral follicles were observed in the ovaries of the treated rats. In these rats serum levels of progesterone were significantly lower, and those of LH were significantly higher than those in control intact rats (2). The present studies were performed to determine (a) how soon after the initiation of the treatment is ovarian progesterone secretion affected by LHRH and its analogues, (b) what are the LH/hCG receptor levels in the ovaries of the rats treated with LHRH and its analogues, and (c) if chronic administration of LH would delay ovum implantation and reduce progesterone levels as was observed in the rats treated with LHRH and its analogues.
KeywordsOvarian Tissue Corpus Luteum Receptor Level Osmotic Minipumps LHRH Analogue
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