Lutropin Induced Desensitization of Rat Ovarian Adenylate Cyclase: A GTP-Dependent Process
Dr. Hunzicker-Dunn has pointed out that desensitization of pig ovarian adenylate cyclase (AC) requires — in addition to high LH concentrations — the presence of ATP. ATP could not be replaced by its non-phosphorylating analogue App(NH)p or by GTP (cf. Bockaert et al. 1). We would like to present evidence that desensitization of ovarian AC is also dependent on the presence of GTP.
KeywordsAdenylate Cyclase Corpus Luteum Cyclase Activity Adenylate Cyclase Activity Sodium Fluoride
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