Inhibitory Effects of Treatment with LHRH or Its Agonists on Ovarian Receptor Levels and Function
We have recently found that treatment of adult male rats with luteinizing hormone-releasing hormone (LHRH) or its agonists leads to a marked loss of testicular LH and prolactin receptor levels accompanied by decreased testis, seminal vesicle and prostate weight as well as lowered plasma testosterone concentration (1, 2). Since LHRH and its agonistic analogues have potent pre- and post-coital antifertility activity in the female rat (3–5) and rabbit (6), it occurred to us that these effects of LHRH and its analogues in the female could also be mediated by endogenous LH-induced desensitization of the ovary. Such a possibility was supported by the findings that treatment with LH or human chorionic gonadotropin (hCG) leads to a marked loss of LH receptors in the ovary accompanied by a reduced ability of LH to stimulate ovarian adenylyl cyclase activity (7).
KeywordsLuteal Phase Receptor Level Marked Loss LHRH Agonist Serum Progesterone
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