Prostaglandin F and Progesterone Release in Vitro by Ovine Luteal Tissue during Induced Luteolysis

  • Caird E. RexroadJr
  • H. D. Guthrie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


Goding (1) has concluded that prostaglandin F (PGF) is a naturally occurring luteolysin in the ewe and that its primary source for luteolysis is the uterus. Patek and Watson (2) have suggested that in the pig the corpora lutea may be involved in bringing about their own demise by PGF synthesis. They observed greater in vitro release of PGF from corpora lutea near the end of the estrous cycle than from corpora lutea during other parts of the cycle. Guthrie et al. (3) have shown that in pigs an injection of Cloprostenol (ICI 80996, a synthetic analogue of PGF) induced luteolysis and increased in vitro PGF release by luteal tissue by 8 hr after the injection. In the present study we investigated factors that affect in vitro synthesis of PGF by luteal tissue in ewes that were injected with Cloprostenol or PGF to induce luteal regression.


Corpus Luteum Estrous Cycle Corpus Luteum Plasma Progesterone Indomethacin Treatment 
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    J. R. Coding. J. Reprod. Fert. 38(1974)261–272.CrossRefGoogle Scholar
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    C. E. Patek and J. Watson. Prostaglandins 12(1976)97–111.CrossRefGoogle Scholar
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    H. D. Guthrie, C. E. Rexroad, Jr. and D. J. Bolt. (1978)in press.Google Scholar
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    C. E.Rexroad, Jr. Biol. Reprod. (1978)in press.Google Scholar
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Caird E. RexroadJr
    • 1
  • H. D. Guthrie
    • 1
  1. 1.U. S. Department of AgricultureSEA BeltsvilleUSA

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