Demonstration of Luteal Cell Membrane Receptors for Prostaglandin F by Ultrastructural and Binding Analysis

  • J. L. Luborsky-Moore
  • K. Wright
  • H. R. Behrman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


Prostaglandins have a ubiquitous distribution and may act on a variety of cell types (1). To date, there have been no studies in which prostaglandin binding sites were directly localized by morphological methods. Prostaglandin F (PGF) has been shown to act directly on isolated rat luteal cells to block luteinizing hormone action (2) and is thought to be involved in luteolysis in vivo (3,4). However, specific binding sites for PGF have not been demonstrated in rat luteal tissue. The purpose of this study was to determine the distribution and specificity of PGF binding sites on cells and membranes isolated from rat luteal tissue by ultrastructural and binding analysis respectively.


Luteal Cell Binding Analysis Ferritin Molecule Corpus Luteum Function Luteinizing Hormone Action 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • J. L. Luborsky-Moore
    • 1
  • K. Wright
    • 1
  • H. R. Behrman
    • 1
  1. 1.Reproductive Biology Section, Depts Ob/Gyn and PharmacologyYale Univ. School MedicineNew HavenUSA

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