In Vitro Release of Progesterone and Prostaglandins F and E by Porcine Luteal and Endometrial Tissue during Induced Luteolysis

  • H. D. Guthrie
  • C. E. RexroadJr.
  • D. J. Bolt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


Prostaglandin F (PGF) has been proposed as the uterine luteolysin in the ewe (1) and pig (2). The corpus luteum (CL) of the pig may also participate in its own demise by means of increased luteal PGF synthesis during luteolysis (3). Both endometrial and luteal PGF synthesis in vitro were higher during the late luteal phase of the cycle than at any other stage of the cycle, but the temporal relationship between endometrial and luteal PGF release in vitro during luteolysis was not established (3). We have found that an increase in endometrial PGF synthesis in vitro starts after day 12 of the cycle, preceding any increase in luteal PGF synthesis in vitro by approximately two days (4).


Luteinizing Hormone Corpus Luteum Endometrial Tissue Superscript Letter Vitro Release 
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  1. (1).
    J.A. McCracken, J.C. Carlson, M.E. Clew, J.R. Coding, D.T. Baird, K. Green and B. Samuelsson, Nature New Biol. 238 (1972) 129.PubMedCrossRefGoogle Scholar
  2. (2).
    F.T. Bazer and W.W. Thatcher, Prostaglandins 14 (1977) 397.PubMedCrossRefGoogle Scholar
  3. (3).
    C.E. Patek and J. Watson, Prostaglandins 12 (1976) 97.PubMedCrossRefGoogle Scholar
  4. (4).
    H.D. Guthrie and C.E. Rexroad, Jr, Proc. ASAS (1978).Google Scholar
  5. (5).
    H.D. Guthrie, J. Anim. Sci. 45 (1977) 1360.PubMedGoogle Scholar
  6. (6).
    C.E. Rexroad, Jr. and H.D. Guthrie, (1978)this volume.Google Scholar
  7. (7).
    K.M. Henderson and K.P. McNatty, Prostaglandins 9 (1975) 77Google Scholar
  8. (8).
    J.M. Marsh, Biol. Reprod. 14 (1976) 30.PubMedCrossRefGoogle Scholar
  9. (9).
    G.W. Duncan, A.M. Bowerman, W.R. Hearn and R.M. Melampy, Proc. Soc. Expt. Biol. Med. 104 (1960) 17.Google Scholar
  10. (10).
    B. Cook, C.C. Kaltenbach, H.W. Norton and A.V. Nalbandov, Endocrinology 81(1967)573.PubMedCrossRefGoogle Scholar
  11. (11).
    J. Watson and J.T.S. Leask, J. Endocrin. 64 (1975) 163.CrossRefGoogle Scholar
  12. (12).
    M. Shemesh and W. Hansel, Biol. Reprod. 13 (1975) 448.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • H. D. Guthrie
    • 1
  • C. E. RexroadJr.
    • 1
  • D. J. Bolt
    • 1
  1. 1.U. S. Department of AgricultureSEABeltsvilleUSA

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