Effects of Cholera Toxin, LH and PGF on Steroidogenesis in Luteal Cells

  • L. J. Dorflinger
  • H. R. Behrman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


Recent studies using cultured rat luteal cells (1) showed that PGF inhibits accumulation of cyclic AMP (cAMP) and progesterone secretion in response to LH, while having little effect on the binding of LH to its receptor. This inhibition of progesterone secretion was reversed by simultaneous addition of exogenous cyclic AMP but not by theophylline (1). It was concluded that PGF2α prevents accumulation of cAMP stimulated by the LH-receptor complex. Secondary factors may mediate the action of PGF2α in intact cells since it does not inhibit LH-stimulated adenylate cyclase activity in isolated luteal membranes (2).


Adenylate Cyclase Corpus Luteum Cholera Toxin Luteal Cell cAMP Accumulation 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • L. J. Dorflinger
    • 1
  • H. R. Behrman
    • 1
  1. 1.Reproductive Biology Section, Departments of Obstetrics, GynecologyPharmacology and Physiology Yale University School of MedicineNew HavenCanada

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