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Prostaglandin F and Its 13-Dehydro Analogs: Comparative Luteolytic Effects in Vivo

  • J. A. McCracken
  • N. Einer-Jensen
  • J. Fried
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)

Abstract

In 1972 prostaglandin F (PGF) was identified as a uterine luteolytic hormone in sheep (1) and there is good evidence to suggest that PGF plays a similar physiological role in the guinea pig (2), in the pig (3; 4), in the cow (5; 6) and probably in other mammalian species (7). However in women and in non-human primates the evidence seems clear that the uterus is not essential for normal cyclic regression of the corpus luteum (8; 9). It would therefore appear that PGs of uterine origin are not the proximate cause of luteolysis in primates. In support of this conclusion it is reported that elevations of the primary metabolite of PGF (15-keto-13: l4-dihydro-PGF) do not occur in the peripheral plasma of women at the time of cyclic regression of the CL (10). This is in contrast to the cow and sheep where major elevations of the primary metabolite coincide with CL regression (6; 11). These metabolite studies thus serve to validate the role of PGF as a uterine luteolytic hormone in the sheep and cow. Nevertheless the possibility that PGs originating within the ovary itself might initiate luteolysis locally in the primate has been suggested by several authors (12; 13; 14). Presumably the amount of PGF so generated within the ovary would be so small that it would not yield sufficient primary metabolite to be detectable in peripheral plasma.

Keywords

Corpus Luteum None None Ovarian Artery Progesterone Secretion Smooth Muscle Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • J. A. McCracken
    • 1
  • N. Einer-Jensen
    • 1
  • J. Fried
    • 2
  1. 1.Worcester Foundation for Experimental BiologyUSA
  2. 2.Department of ChemistryUniversity of ChicagoUSA

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