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Ovarian Follicular and Corpus Luteum Function pp 541–543Cite as

Relationships between Cholesterol Supply and Luteal Mitochondrial Steroid Synthesis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 112))

Abstract

LH acutely increases luteal progestin biosynthesis by stimulating cholesterol side-chain cleavage, a reaction catalyzed by a complex of mitochondrial enzymes containing cytochrome P-450 (1). The steroidogenic action of LH is inhibited by cycloheximide and puromycin, indicating a requirement for protein synthesis (2). It has been suggested that availability of cholesterol governs the rate of side-chain cleavage and that proteins formed under the influence of LH play a role in translocation of cholesterol to the mitochondrial enzyme complex (1,2). In the present study, relationships between cholesterol supply and in vitro steroid synthesis by rat luteal mitochondria were explored.

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References

  1. G.S. Boyd, J.R. Arthur, G.J. Beckett, J.I. Mason and W.H. Trzeciak, J. Steroid Biochem. 6 (1975) 427.

    Article  PubMed  CAS  Google Scholar 

  2. J.R. Arthur and G.S. Boyd, Eur. J. Biochem. 49 (1974) 117.

    Article  PubMed  CAS  Google Scholar 

  3. L.A. Schuler, G.L. Flickinger and J.F. Strauss, III. J. Endocrinol. in press, 1978.

    Google Scholar 

  4. J.R. Robinson and P.M. Stevenson, Eur. J. Biochem. 24 (1971) 18.

    Article  PubMed  CAS  Google Scholar 

  5. S.J. Shattil, R. Anaya-Galindo, J. Bennett, R.W. Colman and R.A. Cooper, J. Clin. Invest. 55 (1975) 636.

    Article  PubMed  CAS  Google Scholar 

  6. T. Omura and R. Sato, J. Biol. Chem. 239 (1964) 2370.

    CAS  Google Scholar 

  7. L.R. Johnson, A. Ruhmann-Wennhold and D.H. Nelson, Ann. N.Y. Acad. Sci. 212 (1973) 307.

    Article  PubMed  CAS  Google Scholar 

  8. G.O. De Villa, K. Roberts, W.G. Wiest, G. Mikhail and G.L. Flickinger, J. Clin. Endocrinol. Metab. 35 (1972) 458.

    Article  Google Scholar 

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Authors and Affiliations

  1. Depts. of OB/GYN and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA

    M. E. Toaff, G. L. Flickinger, J. F. Strauss III & S. J. Shattil

Authors
  1. M. E. Toaff
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  2. G. L. Flickinger
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  3. J. F. Strauss III
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  4. S. J. Shattil
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Cornelia P. Channing

  2. Department of Biochemistry, University of Miami School of Medicine, Miami, Florida, USA

    John M. Marsh

  3. Center for Population Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA

    William A. Sadler

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© 1979 Plenum Press, New York

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Toaff, M.E., Flickinger, G.L., Strauss, J.F., Shattil, S.J. (1979). Relationships between Cholesterol Supply and Luteal Mitochondrial Steroid Synthesis. In: Channing, C.P., Marsh, J.M., Sadler, W.A. (eds) Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3474-3_61

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  • DOI: https://doi.org/10.1007/978-1-4684-3474-3_61

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3476-7

  • Online ISBN: 978-1-4684-3474-3

  • eBook Packages: Springer Book Archive

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