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Relationships between Cholesterol Supply and Luteal Mitochondrial Steroid Synthesis

  • M. E. Toaff
  • G. L. Flickinger
  • J. F. StraussIII
  • S. J. Shattil
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)

Abstract

LH acutely increases luteal progestin biosynthesis by stimulating cholesterol side-chain cleavage, a reaction catalyzed by a complex of mitochondrial enzymes containing cytochrome P-450 (1). The steroidogenic action of LH is inhibited by cycloheximide and puromycin, indicating a requirement for protein synthesis (2). It has been suggested that availability of cholesterol governs the rate of side-chain cleavage and that proteins formed under the influence of LH play a role in translocation of cholesterol to the mitochondrial enzyme complex (1,2). In the present study, relationships between cholesterol supply and in vitro steroid synthesis by rat luteal mitochondria were explored.

Keywords

Steroid Synthesis Lipid Dispersion Steroidogenic Action Mitochondrial Cholesterol Corpus Luteum Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • M. E. Toaff
    • 1
  • G. L. Flickinger
    • 1
  • J. F. StraussIII
    • 1
  • S. J. Shattil
    • 1
  1. 1.Depts. of OB/GYN and MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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