Changes in Ovarian Mitochondria: Early Indicators of Follicular Luteinization
The rapid growth of ovarian follicles occurring after gonadotropic stimulation requires ATP which is obtained primarily from the oxidative reactions in mitochondria. In addition, the rate limiting step of ovarian steroidogenesis appears to be associated with the conversion of cholesterol to pregnenolone by the cholesterol side chain cleavage enzyme complex that is located exclusively within mitochondria. Thus, two of the most important functions of the ovary--follicular growth and steroidogenesis--are dependent upon products produced by mitochondria. For the last few years, we have been studying the role of mitochondria in ovarian physiology and we have been especially interested in the differentiation of ovarian mitochondria that occurs with luteinization of follicular tissue.
KeywordsLuteal Cell Follicular Growth Progesterone Secretion Steroidogenic Cell Ovarian Steroidogenesis
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- (5).M.J. Dimino and S.K. Berman. Submitted for publication.Google Scholar