Evidence That the Pituitary Gland is the Site of Inhibitory Action of Porcine Follicular Fluid upon FSH Secretion in the Rat

  • Phyllis M. Wise
  • Louis V. DePaolo
  • Larry D. Anderson
  • Cornelia P. Channing
  • Charles A. Barraclough
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


This study has examined the effects of porcine follicular fluid (PFF) on the adenohypophyseal secretion of LH and FSH following LHRH treatment. The animal model selected for study was the proestrous rat in which preovulatory LH and FSH surges were blocked with phenobarbital. To elicit the release of gonadotropins from this preparation, two different i.v. LHRH infusion protocols were used. The first elicited a proestrouslike LH and FSH surge while the second infusion schedule evoked the predominant release of FSH with only minor changes in LH. PFF suppressed LHRH-induced FSH secretion in both preparations but had only negligible effects on LH secretion. Interestingly, the suppressive effects of PFF were variable and depended upon the mode in which LHRH was presented.


Pituitary Gland Corpus Luteum Function Porcine Follicular Fluid Water Soluble Testis LHRH Infusion 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Phyllis M. Wise
    • 1
  • Louis V. DePaolo
    • 1
  • Larry D. Anderson
    • 1
  • Cornelia P. Channing
    • 1
  • Charles A. Barraclough
    • 1
  1. 1.Department of PhysiologyUniversity of MarylandBaltimoreUSA

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