Inhibition of in Vivo and in Vitro FSH Secretion by Steroid-Free Hamster Ovarian Extracts
We designed experiments to determine if a nonsteroidal substance capable of inhibiting the secretion of follicle-stimulating hormone (FSH) exists in the hamster ovary. Proestrous hamster ovaries were homogenized, centrifuged, and treated with dextrancoated charcoal for removal of steroids. Charcoal-treated ovarian extract (CTOE) was injected intraperitoneally at hourly intervals into phenobarbital-treated (phen-treated) proestrous hamsters immediately after ovariectomy at 1300. The CTOE inhibited the selective rise in serum FSH that occurred in phen-treated, ovariectomized (ovx) controls.
KeywordsLuteinizing Hormone Follicular Fluid Pituitary Cell Luteinizing Hormone Level Anterior Pituitary Cell
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