Rapid Oocyte Death Prior to and at Puberty in Neonatally Thymectomized Mice

  • Teruto Sakakura
  • Osamu Taguchi
  • Akinori Kojima
  • Yasuake Nishizuka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


It is well established that the thymus plays a critical role in the development of immune systems, especially T-cell participating function. The hypothesis that the thymus is involved in the development of the neuroendocrine system in mammals and that, conversely, neuroendocrine regulation dominates thymic functions, is proposed(l, 2). Based on or not basing on such a hypothesis, experimental data have been accumulating that indicate some interrelation between the thymus and gonads. In 1969, Nishizuka and Sakakura described that thymectomy(Tx) in the mouse at 2–4 days of age leads to complete loss of oocytes, follicles and corpora lutea(3). This ovarian dysgenesis is noticed at 6–9 weeks of age in Tx mice and occurs under thymie regulatory functions and independently of wasting disease(4,5). Similar results, but to a lesser extent, were subsequently reported in mice(6) and in rats(7).


Corpus Luteum Oocyte Maturation Primordial Follicle Lymphocyte Infiltration Mouse Ovary 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Teruto Sakakura
    • 1
  • Osamu Taguchi
    • 1
  • Akinori Kojima
    • 1
  • Yasuake Nishizuka
    • 1
  1. 1.Laboratory of Experimental PathologyAichi Cancer Center Research InstituteNagoya, 464Japan

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