LH-Induced Desensitization of the Adenylyl Cyclase System in Ovarian Follicles

  • Mary Hunzicker-Dunn
  • Richard Jungmann
  • Dennis Derda
  • Lutz Birnbaumer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)

Abstract

The preovulatory surge of LH promotes stimulation, closely followed by desensitization of the ovarian follicular adenylyl cyclase (AC) system (1–6). Desensitization of the AC system in estrous rabbit follicles is characterized by an LH-specific, dose-dependent decline in LH-stimulated AC activity and results, by definition, in a retarded rate of cAMP synthesis (2). Although a coincident decline in LH- and FSH-stimulated AC activities occurs, there is no concurrent decline in prostaglandin (PG)E1- or NaF- stimulated AC activities (2). LH refractoriness is demonstrable within min following mating of the iv injection of an ovulatory dose of hCG and is complete prior to ovulation. The follicular AC system does not acquire LH responsiveness again until 48–72 h after the induction of ovulation, when the new CL has formed. Desensitization of the AC system, then, is clearly one of the earliest events prompted by the surge of LH in follicles. However, little is known concerning the mechanism underlying the desensitizing process.

Keywords

Adenylyl Cyclase Adenylyl Cyclase Activity Graafian Follicle Adenylyl Cyclase System Dephosphorylation Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Mary Hunzicker-Dunn
    • 1
  • Richard Jungmann
    • 1
  • Dennis Derda
    • 1
  • Lutz Birnbaumer
    • 2
  1. 1.Department of BeochemistryNorthwestern University Medical SchoolChicagoUSA
  2. 2.Department of Cell BiologyBaylor College of MedicineHoustonUSA

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