Effects of Follicular Development on the Ability of Cultured Porcine Granulosa Cells to Convert Androgens to Estrogens

  • Larry D. Anderson
  • Frederick W. Schaerf
  • Cornelia P. Channing
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


It has been shown by Channing and her colleagues that as the antral porcine follicle grows from a 2 mm follicle to a 6–12 mm follicle, the granulosa cells exhibit up to a 100 fold increase in LH/hCG receptors (1), an increase in ability to secrete progesterone in culture (2), as well as an increase in ability to respond to LHin terms of cyclic AMP accumulation (3,4). However, changes in the ability to secrete estrogen have not been measured. It has been shown that granulosa cells of many species can secrete estrogen provided they are given androgen substrate (sow (5), mare (6),cow (7), rabbit (8), sheep (9), and rat (10).


Granulosa Cell Follicular Fluid Follicular Development Large Follicle Small Follicle 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Larry D. Anderson
    • 1
  • Frederick W. Schaerf
    • 1
  • Cornelia P. Channing
    • 1
  1. 1.Department of PhysiologyUniversity of Maryland School of MedicineBaltimoreUSA

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