Effects of Follicular Development on the Ability of Cultured Porcine Granulosa Cells to Convert Androgens to Estrogens
It has been shown by Channing and her colleagues that as the antral porcine follicle grows from a 2 mm follicle to a 6–12 mm follicle, the granulosa cells exhibit up to a 100 fold increase in LH/hCG receptors (1), an increase in ability to secrete progesterone in culture (2), as well as an increase in ability to respond to LHin terms of cyclic AMP accumulation (3,4). However, changes in the ability to secrete estrogen have not been measured. It has been shown that granulosa cells of many species can secrete estrogen provided they are given androgen substrate (sow (5), mare (6),cow (7), rabbit (8), sheep (9), and rat (10).
KeywordsGranulosa Cell Follicular Fluid Follicular Development Large Follicle Small Follicle
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