The Control of Ovulation in the Cow by Prostaglandin Inhibitor

  • M. Shemesh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


Recently, it has been shown that follicular fluid from small porcine follicles diminished accumulation of cyclic AMP in response to LH and decreased secretion of progesterone by cultured granulosa cells obtained from large follicles (1). Prostaglandins (PG) have been implicated in the functioning of the gonads mainly in the induction of ovulation-related events. Several investigations have presented evidence demonstrating that prostaglandins are involved in the ovulatory action of luteinizing hormone (LH). Indomethacin, a potent inhibitor of prostaglandin synthesis (2) prevents ovulation in the rat (3–5) and in the rabbit (6, 7). Several authors have also reported that in the rat the ovarian content of PGE (8, 9) and PGF (10) rises shortly after the preovulatory gonadotropin surge. The present study was designed to investigate the possible existence of a factor which might participate in the control of ovulation in non-ovulating bovine follicles by inhibiting PG synthesis by the cultured granulosa cells. The inhibitory effect of follicular fluid on progesterone secretion was also studied.


Luteinizing Hormone Follicular Fluid Large Follicle Atretic Follicle Preovulatory Follicle 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • M. Shemesh
    • 1
  1. 1.Dept. of Hormone ResearchKimron Veterinary InstituteBet-DaganIsrael

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