Regulation of LH(hCG)-Receptor and Adenylate Cyclase in Luteinizing Granulosa Cells

  • Hannu J. Rajaniemi
  • Kalle Jääskeläinen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


The exposure of luteal and testicular tissue in vivo to hCG has been shown to induce a rapid loss of sensitivity of adenylate cyclase (AC) to subsequent LH- or hCG-stimulations. The explanation for this phenomenon appears to be the loss of available receptor sites (1–4). However, the molecular mechanisms of the receptor loss are completely unknown.


Sucrose Filtration EDTA Tyrosine Fluoride 


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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Hannu J. Rajaniemi
    • 1
  • Kalle Jääskeläinen
    • 1
  1. 1.Departments of Anatomy and BiochemistryUniversity of KuopioKuopio 10Finland

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