Regulation of LH(hCG)-Receptor and Adenylate Cyclase in Luteinizing Granulosa Cells

  • Hannu J. Rajaniemi
  • Kalle Jääskeläinen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


The exposure of luteal and testicular tissue in vivo to hCG has been shown to induce a rapid loss of sensitivity of adenylate cyclase (AC) to subsequent LH- or hCG-stimulations. The explanation for this phenomenon appears to be the loss of available receptor sites (1–4). However, the molecular mechanisms of the receptor loss are completely unknown.


Granulosa Cell Adenylate Cyclase Receptor Site Adenylate Cyclase Activity Radioactive Peak 
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  1. (1).
    R.M. Sharpe. Nature 264 (1976) 644.PubMedCrossRefGoogle Scholar
  2. (2).
    A.J.W. Hsueh, M.L. Dufau and K.J. Catt. Biochem.biophys. Res. Commun. 72 (1976) 1145.Google Scholar
  3. (3).
    M. Conti, J.P. Harwood, M.L. Dufau and K.J. Catt. Molec. Pharmacol. 13 (1977) 1024.Google Scholar
  4. (4).
    M.C. Rao, J.S. Richards, A.R. Midgley, Jr. and L.E. Reichert, Jr. Endocrinology 101 (1977) 512.PubMedCrossRefGoogle Scholar
  5. (5).
    F.L. Leidenberger and L.E. Reichert, Jr. Endocrinology 91 (1972) 135.PubMedCrossRefGoogle Scholar
  6. (6).
    C. Nakai and G. Brooker. Biochem.biophys.Acta (Amst.) 391 (1975) 222.CrossRefGoogle Scholar
  7. (7).
    S. Markkanen, K. Töllikkö, T. Vanha-Perttula and H. Rajaniemi. Submitted for publication (1978).Google Scholar
  8. (8).
    S. Fazakerley and D.R. Best. Anal.Biochem. 12 (1965) 290.PubMedCrossRefGoogle Scholar
  9. (9).
    M. Conti, J.P. Harwood, A.J.W. Hsueh, M.L. Dufau and K.J. Catt. J.Biol.Chem. 251 (1976) 7729.PubMedGoogle Scholar
  10. (10).
    M. Ascoli and D. Puett. FEBS Letters 75 (1977) 77.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Hannu J. Rajaniemi
    • 1
  • Kalle Jääskeläinen
    • 1
  1. 1.Departments of Anatomy and BiochemistryUniversity of KuopioKuopio 10Finland

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