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Effect of the Administration of an Ovulatory Dose of HCG on the Subcellular Distribution of Follicular Protein Kinase

  • Mary Hunzicker-Dunn
  • Ming-ann Wang
  • Richard Jungmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)

Abstract

Most protein hormones initate a biological response in their target cells by initially binding to a membrane-localized receptor, thereby activating adenylyl cyclase and raising intracellular levels of cAMP. Currently, the only known manner in which cAMP can mediate cellular function is through cAMP-dependent protein kinases (PK). cAMP has been shown to activate cAMP-dependent PK by binding to the regulatory subunit of the inactive holoenzyme, thereby releasing the active, cAMP-insensitive catalytic subunit which can catalyze the transfer of phosphate form ATP to cellular protein (1). Presumably, the phosphorylation of specific cellular protein(s) regulates cellular activity in such a way that the known hormonal response ensues.

Keywords

Protein Kinase Activity Ovarian Follicle Postovulatory Follicle Graafian Follicle Protein Kinase Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Mary Hunzicker-Dunn
    • 1
  • Ming-ann Wang
    • 1
  • Richard Jungmann
    • 1
  1. 1.Department of BiochemistryNorthwestern University Medical SchoolChicagoUSA

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