Receptors for Gonadotrophins in the Ovine Follicle During Growth and Atresia
Studies in rats (1,2) have shown that granulosa cells of small follicles acquire the capacity to bind FSH and, in the presence of oestrogen, further follicular development is accompanied by formation of antral fluid and the appearance of receptors for LH on the granulosa. LH binding to these receptors results in a loss of receptor and induces differentiation of granulosa to luteal cells which in the presence of prolactin and LH, will secrete progesterone. In the sheep, follicles may undergo degeneration i.e. atresia at any stage of the oestrous cycle (3) and in all sizes of follicles (4). The relationship between gonadotrophin binding and atresia is not clear, although atresia is known to be associated with loss of LH receptor in rat granulosa cells (5).
KeywordsGranulosa Cell Follicular Fluid Luteal Cell Large Follicle Atretic Follicle
Unable to display preview. Download preview PDF.
- (7).M.F. Hay, D.G. Cran and R.M. Moor. Cell. Tiss. Res. 169 (1976) 575.Google Scholar
- (8).R.M. Moor, M.F. Hay, H.M. Dott and D.G. Cran. J. Endocrinol. (77(1978) in press.Google Scholar
- (14).B. Falck. Acta. Physiol. Scand. (Suppl.) 47 (1959) 163.Google Scholar
- (15).D.T. Baird, in: Endocrinology, Vol. 1, ed. V.H.T. James ( Excerpta, Amsterdam, 1977 ) p. 330.Google Scholar
- (16).D.T. Baird. J. Reprod. Fert. 50(1977)183.Google Scholar
- (20).R.S. Carson, J.K. Findlay, H.G. Burger and A.O. Trounson. Biol. Reproduction — submitted for publication (1978).Google Scholar