Receptors for Gonadotrophins in the Ovine Follicle During Growth and Atresia

  • R. S. Carson
  • J. K. Findlay
  • H. G. Burger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 112)


Studies in rats (1,2) have shown that granulosa cells of small follicles acquire the capacity to bind FSH and, in the presence of oestrogen, further follicular development is accompanied by formation of antral fluid and the appearance of receptors for LH on the granulosa. LH binding to these receptors results in a loss of receptor and induces differentiation of granulosa to luteal cells which in the presence of prolactin and LH, will secrete progesterone. In the sheep, follicles may undergo degeneration i.e. atresia at any stage of the oestrous cycle (3) and in all sizes of follicles (4). The relationship between gonadotrophin binding and atresia is not clear, although atresia is known to be associated with loss of LH receptor in rat granulosa cells (5).


Granulosa Cell Follicular Fluid Luteal Cell Large Follicle Atretic Follicle 
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  1. (1).
    J.S. Richards and A.R. Midgley Jnr., Biol. Reprod. 14 (1976) 82.PubMedCrossRefGoogle Scholar
  2. (2).
    H.J. Rajaniemi, A.R. Midgley Jnr., J.A. Duncan and L. E. Reichert Jnr. Endocrinology 101 (1977) 898.PubMedCrossRefGoogle Scholar
  3. (3).
    A. Brand and W.H.R. de Jong. J. Reprod. Fert. 33 (1973) 431.CrossRefGoogle Scholar
  4. (4).
    K.E. Turnbull, A.W.H. Braden and P.E. Mattner. Aust. J. Biol. Sci. 30 (1977) 229.PubMedGoogle Scholar
  5. (5).
    J.J. Peluso, R.W. Steger and E.S.E. Hafez. J. Reprod. Fert. 49 (1977) 215.CrossRefGoogle Scholar
  6. (6).
    R.M. Moor, M.F. Hay, J.E.A. McIntosh and B.V. Caldwell. J. Endocrinol. 58 (1973) 599.PubMedCrossRefGoogle Scholar
  7. (7).
    M.F. Hay, D.G. Cran and R.M. Moor. Cell. Tiss. Res. 169 (1976) 575.Google Scholar
  8. (8).
    R.M. Moor, M.F. Hay, H.M. Dott and D.G. Cran. J. Endocrinol. (77(1978) in press.Google Scholar
  9. (9).
    Y. Miyachi, J.L. Vaitukaitis, E. Nieschlag and M.B. Lipsett. J. Clin. Endoc. Metab. 34 (1972) 23.CrossRefGoogle Scholar
  10. (10).
    S. Kammerman and R.E. Canfield. Endocrinology 90 (1972) 384.PubMedCrossRefGoogle Scholar
  11. (11).
    K.W. Cheng. J. Clin. Endoc. Metab. 41 (1975) 58.CrossRefGoogle Scholar
  12. (12).
    C.Y. Lee and R.J. Ryan. Endocrinology 89 (1971) 1515.PubMedCrossRefGoogle Scholar
  13. (13).
    O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall. J. Biol. Chem. 193 (1951) 265.PubMedGoogle Scholar
  14. (14).
    B. Falck. Acta. Physiol. Scand. (Suppl.) 47 (1959) 163.Google Scholar
  15. (15).
    D.T. Baird, in: Endocrinology, Vol. 1, ed. V.H.T. James ( Excerpta, Amsterdam, 1977 ) p. 330.Google Scholar
  16. (16).
    D.T. Baird. J. Reprod. Fert. 50(1977)183.Google Scholar
  17. (17).
    M.F. Hay and R.M. Moor. J. Reprod. Fert. 43 (1975) 313.CrossRefGoogle Scholar
  18. (18).
    C.P. Channing and S.P. Coudert. Endocrinology 98 (1976) 590.PubMedCrossRefGoogle Scholar
  19. (19).
    J.H. Dorrington, Y.S. Moon and D.T. Armstrong. Endocrinology 97 (1975) 1328.PubMedCrossRefGoogle Scholar
  20. (20).
    R.S. Carson, J.K. Findlay, H.G. Burger and A.O. Trounson. Biol. Reproduction — submitted for publication (1978).Google Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • R. S. Carson
    • 1
  • J. K. Findlay
    • 1
  • H. G. Burger
    • 2
  1. 1.Reproduction Research SectionUniversity of MelbourneParkvilleAustralia
  2. 2.Medical Research CentrePrince Henry’s HospitalMelbourneAustralia

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