Methylation of Transfer Ribonucleic Acid

  • F. Cimino
  • C. Traboni
  • P. Izzo
  • F. Salvatore


The central role of transfer ribonucleic acid (tRNA) in the multistep mechanism of cellular protein biosynthesis justifies by itself the existence of a variety of specific molecules, all of which appear to have a spatial structure basically similar to each other. Moreover, in recent years several other roles of tRNA, besides the structural ones (i.e., those related to the formation of a protein), have been shown to be related to some regulatory cellular processes (1,2). Therefore, a variety of tRNA molecules exists within a single cell (up to 50–60 species), which is due to the different primary sequence of the four major nucleosides, as well as to a series of modified, or minor nucleosides which are formed at posttrancriptional level. Among these modifications, methylation is the most frequent, both in prokaryote and in eukaryote cells, allowing the formation of a variety of methylated nucleosides, which represent up to 50 per cent of the total number of the modified nucleosides (more than 50 have been identified so far) (3).


tRNA Molecule tRNA Species Modify Nucleoside Polynucleotide Chain Methylase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • F. Cimino
    • 1
  • C. Traboni
    • 1
  • P. Izzo
    • 1
  • F. Salvatore
    • 1
  1. 1.Istituto di Chimica Biologica 2 Facoltà di Medicina e ChirurgiaUniversità di NapoliNapoliItaly

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