On the Principles of Nucleic Acid — Protein Interaction
The difficulty of establishing recognition between partners with different molecular “languages”, proteins and nucleic acids is by-passed by two mechanisms, in which the principle of coupling factors of opposite character, unity and diversity, integrated in one single molecular structure is operative. For free aminoacids it is the adaptor mechanism, the anti-codon of tRNA playing a dual role. In the protein-DNA interaction hydrogen bonds are established with the components of the common, ever-repeating peptide bond. A kind of “recognition code” can be formulated.
KeywordsPeptide Bond Minor Groove tRNA Molecule Polynucleotide Chain Recognition Code
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