P300 -- Thirteen Years Later

  • Samuel Sutton
Part of the The Downstate Series of Research in Psychiatry and Psychology book series (DSRPP, volume 2)


It was 13 years ago, almost to the day, in the spring of 1964 that we first observed P300.1 The size of the component impressed us a great deal. Over the years, we were even more impressed with its reliability. In hundreds of experiments with normal subjects, using many variations of the original design, P300 was always found to be larger the greater the amount of uncertainty resolved.


P300 Amplitude P300 Latency Clinical Neurophysiology Uncertain Condition Time Judgment 
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  1. Adams, J.C., & Benson, D.A. Task-contingent enhancement of the auditory evoked response.Electroencephalography and Clinical Neurophysiology, 1973, 35, 249–257.PubMedCrossRefGoogle Scholar
  2. Begleiter, H., Gross, U.M., & Kissin, B. Evoked cortical responses to affective visual stimuli.Psychophysiology, 1967, 3, 336– 344.PubMedCrossRefGoogle Scholar
  3. Brown, W.S., Marsh, J.T., & Smith, J.C. Evoked potential waveform differences produced by the perception of different meanings of an ambiguous phrase.Electroencephalography and Clinical Neurophysiology, 1976, 41 ,113–123,PubMedCrossRefGoogle Scholar
  4. Donchin, E. Average evoked potentials and uncertainty resolution.Psychonomic Science, 1968, 12, 103.Google Scholar
  5. Donchin, E., Kubovy, M., Kutas, M., Johnson, R., Jr., & Herning, R.I. Graded changes in evoked response (P300) amplitude as a function of cognitive activity.Perception & Psychophysics, 1973, 14, 319–324.CrossRefGoogle Scholar
  6. Ford, J.M., Roth, W.T., & Kopell, B.S. Auditory evoked potentials to unpredictable shifts in pitch.Psychophysiology, 1976,13, 32–39.PubMedCrossRefGoogle Scholar
  7. Friedman, D., Hakerem, G., Sutton, S., & Fleiss, J.L. Effect of stimulus uncertainty on the pupillary dilation response and the vertex evoked potential.Electroencephalography and Clini cal Neurophysiology, 1973, 34, 475–484.CrossRefGoogle Scholar
  8. Hillyard, S.A., Squires, K.C., Bauer, J.W., & Lindsay, P.H. Evoked potential correlates of auditory signal detection.Science, 1971,172, 1357–1360.PubMedCrossRefGoogle Scholar
  9. John. E.R., Kerrington, R., & Sutton, S. Effects of visual form on the evoked response.Science, 1967, 155, 1439–1441.PubMedCrossRefGoogle Scholar
  10. Johnson, R., Jr., & Donchin, E. On how P300 amplitude varies with the utility of the eliciting stimuli.Electroencephalography and Clinical Neurophysiology, in press.Google Scholar
  11. Kutas, M., McCarthy, G., & Donchin, E. Augmenting mental chrono-metry: the P300 as a measure of stimulus evaluation time.Science, 1977,197, 792–795.PubMedCrossRefGoogle Scholar
  12. Lang, P.J., Gatchel, R.J., & Simons, R.F. Electrocortical and cardiac rate correlates of psychophysical judgment.Psycho physiology, 1975, 12, 649–655.Google Scholar
  13. Mast, T.E., & Watson, C.S. Attention and auditory evoked responses to low detectability signals.Perception & Psychophysics, 1968, 4, 237–240.CrossRefGoogle Scholar
  14. Mowrer, O.H. Preparatory set (expectancy)-Further evidence of its’central’locus.Journal of Experimental Psychology, 1941, 28, 116–133.CrossRefGoogle Scholar
  15. Mowrer, O.H., Rayman, N.N., & Bliss, E.L. Preparatory set (expectancy)-An experimental demonstration of its’central’locus.Journal of Experimental Psychology, 1940, 26, 357–372.CrossRefGoogle Scholar
  16. Paul, D.D., & Sutton, S. Evoked potential correlates of response criterion in auditory signal detection.Science, 1972,177, 362–364.PubMedCrossRefGoogle Scholar
  17. Purves, S.J.S.The effect of the geometric form and meaning of the stimulus on the configuration of the visual evoked response. Unpublished doctoral dissertation, The University of British Columbia, 1976.Google Scholar
  18. Ritter, W., Simson, R., & Vaughan, H.G. Association cortex potentials and reaction time in auditory discrimination.Electroencephalography and Clinical Neurophysiology, 1972, 33, 547–555.PubMedCrossRefGoogle Scholar
  19. Ruchkin, D.S., & Sutton, S. Emitted P300 potentials and temporal uncertainty.Electroencephalography and Clinical Neurophysio logy, in press, (a)Google Scholar
  20. Ruchkin, D.S., & Sutton, S. Equivocation and P300 amplitude. In D. Otto (Ed.),Multidisciplinary perspectives in event-related brain potential research, Washington, D.C.: U.S. Government Printing Office, in press, (b)Google Scholar
  21. Ruchkin, D.S., & Sutton, S. Latency characteristics and trial-by-trial variations of emitted cerebral potentials. In J.E. Desmedt (Ed.),Progress in clinical neurophysiology. (Vol. 6).Cognitive components in cerebral event-related potentials and selective attention. Basel: S. Karger, 1978.Google Scholar
  22. Simons, R.F., & Lang, P.J. Psychophysical judgment: electrocortical and heart rate correlates of accuracy and uncertainty.Biological Psychology, 1976, 4, 51–64.PubMedCrossRefGoogle Scholar
  23. Squires, K.C., Hillyard, S.A., & Lindsay, P.K. Cortical potentials evoked by confirming and disconfirming feedback following an auditory discrimination.Perception & Psychophysics, 1973, 13, 25–31.CrossRefGoogle Scholar
  24. Squires, K.C., & Squires, N.K. Vertex evoked potentials in a rating-scale detection task: relation to signal probability.Behavioral Biology, 1975, 13, 21–34.PubMedCrossRefGoogle Scholar
  25. Squires, K.C., Squires, N.K., & Hillyard, S.A. Decision-related cortical potentials during an auditory signal detection task with cued observation intervals.Journal of Experimental Psy chology: Human Perception and Performance, 1975, 1, 268–279.CrossRefGoogle Scholar
  26. Squires, N.K., Donchin, E., Squires, K.C., & Grossberg, S. Bi-sensory stimulation: inferring decision-related processes from the P300 component.Journal of Experimental Psychology: Human Perception and Performance, 1977,3,299–315.PubMedCrossRefGoogle Scholar
  27. Sutton, S., Braren, M., Zubin, J., & John, E.R. Evoked potential correlates of stimulus uncertainty.Science, 1965,150, 1187–1188.PubMedCrossRefGoogle Scholar
  28. Sutton, S., Tueting, P., Hammer, M., & Hakerem, G. Evoked potentials and feedback. In D. Otto (Ed.),Multidisciplinary per spectives in event-related brain potential research. Washington, D.C.: U.S. Government Printing Office, in press.Google Scholar
  29. Sutton, S., Tueting, P., Zubin, J., & John, E.R. Information delivery and the sensory evoked potential.Science, 1967,155, 1436–1439.PubMedCrossRefGoogle Scholar
  30. Thatcher, R.W. Evoked potential correlates of hemispheric lateralization during semantic information processing. In S. Harnad, R. Doty, L. Goldstein, J. Jaynes, G. Krauthamer (Eds.),Later alization in the nervous system. New York: Academic Press, 1977.Google Scholar
  31. Thurmond, J.B., & Alluisi, E.A. Choice time as a function of stimu-stimulus dissimilarity and discriminability.Canadian Journal of Psychology, 1963, 17, 326–337.PubMedCrossRefGoogle Scholar
  32. Tueting, P., & Levit, R.A. Long-term changes of event-related potentials in normals, depressives and schizophrenics. In J.E. Desmedt (Ed.),Progress in clinical neurophysiology. (Vol. 6).Cognitive components in cerebral event-related potentials and selective attention. Basel: S. Karger, 1978.Google Scholar
  33. Tueting, P., Sutton, S., & Zubin, J. Quantitative evoked potential correlates of the probability of events.Psychophysiology, 1970, 7, 385–394.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Samuel Sutton
    • 1
  1. 1.Department of PsychophysiologyNew York State Psychiatric InstituteNew YorkUSA

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