The Biological Axis of Senescence, Stress, and Aging as Construct for Cancer, Disease, and Death

  • Stacey B. Day
  • O. Garzon Duhov
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)


It is a fact that over long years of intellectual, innovative, and practical biologic research, not to mention the disbursement of vast sums of money, the experimental sciences have in the main focused their efforts on deriving an understanding of life. Few, if any, research studies have attempted to understand death at the molecular level. Such death presumably is the end point of all life, and in that sense is as naturally and as inextricably tied to the life process as is birth. Declining and dying are fundamental parts of the evolutionary chain including life, and clearly death is as much a process built into the biophysiologic whole as are stress, metabolism, growth, regeneration, aging, disease, and other “life” functions. The dearth of experimental studies addressed to the subject of death is in marked contrast to the surfeit of writing on the moral order, for whether provoked by conscience or not, philosophic and metaphysical writings are no strangers to the bibliographical index of death studies. In recent years (Day, 1971, 1973) cultural anthropology and sociology (Calhoun, 1973) have added thrust to this dimension. The time is certainly Appropriate to urge encouragement of basic research into the mechanisms of the death process.


Core Body Temperature Maximum Life Span Fresh Start Human Diploid Cell Strain Normal Diploid Cell 


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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Stacey B. Day
    • 1
  • O. Garzon Duhov
    • 1
  1. 1.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

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