Abstract
The complex pathological changes which we collectively call cancer present a series of complicated interactions within the interrelated systems of the body. It is not unreasonable, therefore, that consideration should be given to the possible ways in which the malignant process and the higher centers of the nervous system interact. Although a good deal of attention has been given to the consequences of malignancy on the central nervous system apart from the mechanical effects of metastasis, there is a growing awareness that the areas of the brain collectively concerned with emotions may in turn modify the development and progression of cancer. It is this latter aspect which will be considered in this paper.
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References
Foulds, L. Neoplastic Development, Vol. 2. New York: Academic Press, 1975, p. 228.
Ehrlich, P. Croonian lecture on immunity with special reference to cell life. Proc. Royal Soc. Med. 66:42A, 1900.
Lewis, M. G. Immunology and the melanomas. Curr. Top. Microbiol. Immunol. 63:49, 1974.
Vaage, J. Protective serum effects in tumor immunity. Israel J. Med. Sci. 12:334, 1976.
Morton, D. L. Cancer immunotherapy: An overview. Setnin. Oncol. 1:297, 1974.
Jerry, L. M., Lewis, M. G., and Cano, P. O. Anergy, anti-antibodies and immune complex disease: A syndrome of disordered immune regulation in human cancer. In Martin, M., and Dionne, L. (Eds.), Immunocancerology in Solid Tumors. Québec: Septième Symposium de Cancérologie, Faculté de Médecine de l’Université Laval, 1976.
Lewis, M. G., Phillips, T. M., Rowden, G., and Jerry, L. M. Humoral immune reactions in cancer patients. In Handbook of Cancer Immunology. New York: Garland, 1977, p. 159.
Rahe, R. H. Subjects’ recent life changes and their near-future illness susceptibility. Adv. Psychosom. Med. 8:2,1972.
Jacobs, M. A., Spilken, A., and Norman, M. Relationship of life change, maladaptive aggression, and upper respiratory infection in male college students. Psychosom. Med. 31:31, 1969.
Palmblad, P., Cantell, K., Strander, H., Froberg, J., Karlsson, C. G., Levi, L., Granstrom, M., and Unger, P. Stressor exposure and immunological response in man: Interferon-producing capacity and phagocytosis. J. Psychol. Res. 20:193, 1976.
Soloman, G. F., Amkraut, A. A., and Kasper, P. Immunity, emotions and stress. Ann. Clin. Res. 6:313, 1974.
Stein, M., Schiavi, R. C, and Camerino, M. Influence of brain and behavior on the immune system. Science 191:435, 1976.
Van den Brenk, H. A. S., Stone, M. G., Kelly, H., and Sharpington, C. Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress. Brit. J. Cancer 33:60, 1976.
Joãsoo, A., and McKenzie, J. M. Stress and the immune response in rats. Int. Archs. Allergy Appl. Immunol. 50:659, 1976.
Peters, L. J., and Kelly, H. The influence of stress and stress hormones on the transplantability of a non-immunogenic syngeneic murine tumor. Cancer 39:1482, 1977.
Ebbesen, P., and Rask-Kielsen, R. Influence of sex-segregated grouping and of inoculation of subcellular leukemic material on development of non-leukemic lesions in DBA/2, BALB/c, and CBA mice. J. Nat. Cancer Inst. 39:917, 1967.
Monjan, A. A., and Collector, M. I. Stress-induced modulation of the immune response. Science 196:307, 1977.
Hamilton, D. R. Immunosuppressive effects of predator induced stress in mice with acquired immunity to Hymenolepis nana. J. Psychol. Res. 18:143, 1974.
Soloman, G. F., Amkraut, A. A., and Kasper, P. Immunity, emotions, and stress. With special reference to the mechanisms of stress effects on the immune system. Psychother. Psychosom. 23:209, 1974.
Lewis, M. G., Hartmann, D., and Jerry, L. M. Antibodies and anti-antibodies in human malignancy: An expression of deranged immune regulation. Ann. N.Y. Acad. Sci. 276:316, 1976.
Jerne, N. K. Immune regulation in a lymphocyte network. In Edelman, G. M. (Ed.), Cellular Selection and Regulation in the Immune Response. New York: Raven Press, p. 39, 1974.
Metchnikiff, E. Immunity in infective disease. Translated by F. G. Binnie. In The Sources of Science Handbooks, No. 61. New York and London: Johnson Reprint Corporation, p. 569, 1968.
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Lewis, M.G., Phillips, T.M. (1978). The Possible Effects of Emotional Stress on Cancer Mediated through the Immune System. In: Taché, J., Selye, H., Day, S.B. (eds) Cancer, Stress, and Death. Sloan-Kettering Institute Cancer Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3459-0_3
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DOI: https://doi.org/10.1007/978-1-4684-3459-0_3
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